Activation-induced mobilization of secretory vesicles in bovine neutrophils

Swain, Steve D.; Siemsen, Daniel W.; Hanson, Angela J.; Quinn, Mark T.

doi:10.2460/ajvr.2001.62.1776

Cited by 11 publications

(3 citation statements)

References 43 publications

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“…The increase of NAP upon bacterial infection suggests that NAP might be closely related to neutrophils' function and the regression of inflammation. Steve D et al [22] found bovine neutrophils respond to various inflammatory mediators by mobilizing alkaline phosphatase-containing secretory granules, which suggested that the process was an important early step in the host-defense response of bovine neutrophils.…”

Section: Discussionmentioning

confidence: 99%

Critical role of neutrophil alkaline phosphatase in the antimicrobial function of neutrophils

Zhao

et al. 2016

Life Sciences

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Section: Discussionmentioning

confidence: 99%

Critical role of neutrophil alkaline phosphatase in the antimicrobial function of neutrophils

Zhao

et al. 2016

Life Sciences

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“…The cells of the innate and adaptive immune systems are both identified to be influenced by E 2 (Blesson, 2011;Karpuzoglu and Zouali, 2011;Dragin et al, 2017). El-Banna and Hafez (1972) and Marinov and Lovell (1967) have proposed that E2 serum levels are reported to be lowest during the estrus stage of the estrous cycle causing cervical mucus to be secreted in bovines. Accordingly, Kumar et al (2021) identified that the serum concentration of E 2 in normal estrus Murrah buffaloes (animals showing signs of heat) was significantly higher when compared to the silent estrus animals (animals not showing signs of heat).…”

Section: Urinary Exosome Shbg Levels In G-i G-ii and G-iii Animalsmentioning

confidence: 99%

“…The results of the present study are in contrast to the findings of Vesanen et al (1990) who reported the circulatory levels of SHBG at the estrus as well as diestrus stage to be almost similar. Further, it appears that the significantly lower levels of SHBG in urinary exosomes of G-II and G-III animals could be due to lower levels of circulatory SHBG at the estrus stage (Mousavi and Adlercreutz, 1993;Hammond, 2002;Wallen and Hassett 2009), as E 2 needs to exert its action in the female reproductive tract (Marinov and Lovell 1967;El-Banna and Hafez, 1972).…”

Section: Quantification Of Urinary Exosome Sex Hormone Binding Globul...mentioning

confidence: 99%

Quantification of Urinary Exosome Sex Hormone Binding Globulin Levels during Estrus and Diestrus Stages of Buffaloes

Varra,

Kumar,

Chandranaik

et al. 2023

ASD

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Background: The efficiency of reproduction in buffaloes can be increased by being able to spot buffaloes in estrus, as silent heat is a severe problem in this species. Proteins of urinary exosomes are identified to be better physiological biomarkers when compared to cell free proteins as these extracellular vesicles (EVs) are tiny in size, have additional protection from degradation by endogenous protease activity and are involved in intercellular communication. Hence, the present study was aimed to quantify the urinary exosome sex hormone binding globulin (SHBG) levels during estrus and diestrus stages of buffaloes to determine its suitability as a marker for identifying buffaloes in estrus. Methods: The grouping of animals as mid-diestrus (Group-I/G-I/Control group), regular estrus (Group-II/G-II) and silent estrus (Group-III/G-III) buffaloes was done using a combinatorial approach. The levels of SHBG in urinary exosomes of three groups of animals was quantified using the bovine SHBG ELISA kit. Result: The present study’s findings showed significantly higher urinary exosome SHBG concentration (p less than 0.05) in G-I in comparison to G-II and G-III. The present study revealing for decreased concentration of urinary exosome SHBG in G-II and G-III animals when compared to G-I animals probably construes the physiological role of SHBG in the female reproductive tract at the estrus stage by mediating the action of estradiol 17 â (Eα) at the target site. However, for urinary exosome SHBG to be considered as a biomarker, there is need for additional research on a bigger population.

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Bovine neutrophils in health and disease

Bassel

Caswell

2018

Cell Tissue Res

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Bovine neutrophils have similarities to those of other species with respect to mechanisms of their activation and migration into tissue, modulation of immune responses and the balance between microbial killing and host tissue damage. However, bovine neutrophils have biochemical and functional differences from those of other species, which may yield insights about the comparative biology of neutrophils. Neutrophils play protective and harmful roles in the infectious diseases of cattle that occur at times of transition: respiratory disease in beef calves recently arrived to feedlots and mastitis and other diseases of postparturient dairy cows. An important research focus is the mechanisms by which risk factors for these diseases affect neutrophil function and thereby lead to disease and the prospect of genetic or pharmacologic improvement of disease resistance. Further, in keeping with the One Health paradigm, cattle can be considered a model for studying the role of neutrophils in naturally occurring diseases caused by host-adapted pathogens and are thus an intermediary between studies of mouse models and investigations of human disease. Finally, the study of bovine neutrophils is important for agriculture, to understand the pathogenesis of these production-limiting diseases and to develop novel methods of disease prevention that improve animal health and reduce the reliance on antimicrobial use.

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Activation-induced mobilization of secretory vesicles in bovine neutrophils

Abstract: Bovine neutrophils respond to various inflammatory mediators by mobilizing alkaline phosphatase-containing secretory granules. This suggests that the process is an important early step in the host-defense response of bovine neutrophils.

Cited by 11 publications

References 43 publications

Critical role of neutrophil alkaline phosphatase in the antimicrobial function of neutrophils

Critical role of neutrophil alkaline phosphatase in the antimicrobial function of neutrophils

Quantification of Urinary Exosome Sex Hormone Binding Globulin Levels during Estrus and Diestrus Stages of Buffaloes

Bovine neutrophils in health and disease

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