Activation of 5-HT2 receptors inhibits the evoked release of [3H]noradrenaline in the rat spinal cord

5-HT Receptor Regulation of Neurotransmitter Release

“…3 H]NA release in a manner sensitive to blockade by ketanserin at a concentration that does not discriminate between 5-HT 2 receptor subtypes (Celuch et al, 1992). However, in view of the facilitatory character of the 5-HT 2 receptors (as a rule, coupled to G q proteins), a location of the 5-HT 2 receptors on the noradrenergic nerve terminals is improbable; such facilitatory receptor systems, stimulation of which ultimately results in an inhibitory function, probably occur on a neuron releasing an inhibitory neurotransmitter onto the noradrenergic axon terminal.…”

The Pharmacology of Pain

“…This action may involve a facilatory action on P AF terminals reflecting the induction of phospholipase C and subsequently protein kinase C (HORI et al 1996). On the other hand, an inhibition of DH release of NAD may also be implicated (CELUCH et al 1992). The above observations suggest that a further clarification of the roles of 5-HTzA, 5-HTzB and 5-HTzc receptors in the modulation of nociception at the spinal level would be of interest.…”