Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting

Bellacosa, Alfonso; Kumar, Chandan; Cristofano, Antonio Di; Testa, Joseph R.

doi:10.1016/s0065-230x(05)94002-5

Cited by 735 publications

(694 citation statements)

References 214 publications

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“…13 Elevated 11 mRNA levels of ST6Gal I and ST3Gal V positively correlated with the high risk of 12 pediatric acute leukemia. 12 Endogenous expression of ST6GalNAc I in CML cell line 13 K562 was associated with the expression of the STn O-Glycan related to a lack of 14 response to chemotherapy. 14 Yamada I (GD3 synthase) was down regulated in childhood ALL while was up-regulated in 17 adult T-cell leukemia cell lines.…”

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confidence: 99%

“…3 Nowadays, many 9 researchers are struggling to adequately evaluate the relationship between glycan 10 alterations and resistance to chemotherapy of cancer cells. However, there is still little 11 information about the role of glycosyltransferases in the development of leukemia 12 MDR in spite of the modification of glycan structures have been observed in 13 drug-resistance leukemia cells. 4, 5 14 Cell-surface glycoproteins commonly contain sialic acid (SA) as a 15 monosaccharide located on the nonreducing terminus of glycans.…”

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confidence: 99%

“…ST3Gal V was found 8 predominantly expressed in childhood acute lymphoblastic leukemia (ALL). 12 High 9 level of ST3Gal III, an enzyme catalyzing Sialyl-Lewis X (SLX) synthesis, produced 10 cellular resistance to Taxol and thus reduced the efficacy of Taxol therapy. 13 Elevated 11 mRNA levels of ST6Gal I and ST3Gal V positively correlated with the high risk of 12 pediatric acute leukemia.…”

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confidence: 99%

“…12 High 9 level of ST3Gal III, an enzyme catalyzing Sialyl-Lewis X (SLX) synthesis, produced 10 cellular resistance to Taxol and thus reduced the efficacy of Taxol therapy. 13 Elevated 11 mRNA levels of ST6Gal I and ST3Gal V positively correlated with the high risk of 12 pediatric acute leukemia. 12 Endogenous expression of ST6GalNAc I in CML cell line 13 K562 was associated with the expression of the STn O-Glycan related to a lack of 14 response to chemotherapy.…”

mentioning

confidence: 99%

“…14 Yamada I (GD3 synthase) was down regulated in childhood ALL while was up-regulated in 17 adult T-cell leukemia cell lines. 12 Polysialic acid (PSA) formed by ST8Sia II and 18 ST8Sia IV has been found on the unidentified proteins in basophilic leukemia cell 19 lines. 16 In order to inhibit MDR of AML targeting of ST genes could be applied to 20 cancer therapy.…”

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confidence: 99%

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Downregulation of miR‐199a/b‐5p is associated with GCNT2 induction upon epithelial–mesenchymal transition in colon cancer

Chao

Huang

et al. 2017

FEBS Letters

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β-1,6-N-acetylglucosaminyltransferase 2 (GCNT2), which encodes a key glycosyltransferase for blood group I antigen synthesis, is induced upon epithelial-mesenchymal transition (EMT). Our results indicate that GCNT2 is upregulated upon EMT induced with epidermal growth factor and basic FGF in cultured human colon cancer cells. GCNT2 knockdown or overexpression decreases or increases, respectively, malignancy-related characteristics of colon cancer cells and I antigen levels. MiR-199a/b-5p is markedly downregulated upon EMT in colon cancer cells. Here, we find that miR-199a/b-5p consistently regulates GCNT2 expression in reporter assays and that it binds directly to the GCNT2 3' untranslated region intracellularly in RNA-induced silencing complex-trap assays. Overexpression of miR-199a/b-5p decreases GCNT2 expression and suppresses I antigen production. Based on these findings, we propose that miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT.

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