Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein

Xia, Cong; Wu, You; Dai, De‐Zai; Ding, Mingjian; Zhang, Yun; Yin, Dong

doi:10.1111/j.2042-7158.2012.01507.x

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Indomethacin has analgesic, antipyretic, and antiinflammatory activity that is mediated by inhibition of COX-1 and COX-2 [Nalamachu and Wortmann, 2014]. Indomethacin can also inhibit the human multidrug resistance protein MRP4, thus blocking the prostaglandin efflux transporter [Reid et al, 2003], can also decrease neutrophil migration and paw edema [Albuquerque et al, 2009], induce nitric oxide production, reduce glutathione and malondialdehyde formation, reduce NF-jB mRNA expression [El-Shitany et al, 2014] and suppress aquaporin 4, endoplasmic reticulum stress and p66Shc gene expression [Cong et al, 2012]. Additionally, the potential participation of adrenaline, adrenoceptors and prednisolone in indomethacin-induced anti-inflammatory activity has been suggested [Suleyman et al, 2008].…”

Section: Anti-inflammatory Effects Induced By Indomethacin-mce Combinmentioning

confidence: 99%

Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan‐Induced Paw Inflammation in Rats

Ortiz

Cariño-Cortés

Ponce‐Monter

et al. 2017

Drug Development Research

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Preclinical Research The coadministration of non-steroidal anti-inflammatory drugs (NSAIDs) with medicinal plant extracts may increase anti-inflammatory activity, thus permitting the use of lower NSAID doses and limiting the side effects. The aim of this study was to explore the interactions between an ethanolic extract of M. chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats. Diclofenac, indomethacin and MCE, or combinations with MCE produced an anti-inflammatory effect. Effective dose (ED) values were estimated for the individual drugs, and isobolograms were constructed. The final experimental ED values were 483.7 mg/kg for diclofenac + MCE combination, and 212.6 mg/kg for indomethacin + MCE. These values were lower (p < 0.05) than the theoretical ED values (1186.9 mg/kg for diclofenac + MCE combination, and 1183.8 mg/kg for indomethacin + MCE). These data suggest that the interactions between NSAIDs and MCE that mediate the anti-inflammatory effects at the systemic level are synergistic and may have therapeutic advantages for the clinical treatment of inflammatory processes. Drug Dev Res 78 : 360-367, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Anti-inflammatory Effects Induced By Indomethacin-mce Combinmentioning

confidence: 99%

Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan‐Induced Paw Inflammation in Rats

Ortiz

Cariño-Cortés

Ponce‐Monter

et al. 2017

Drug Development Research

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“…However, the effects of rhein on ATF-6 are not all positive. Rhein can also significantly inhibit ATF-6 activation to exert its anti-inflammatory activity (Cong et al, 2012a , b ). In general, rhein can apparently upregulate ER stress, while the regulation on ATF-6 is controversial.…”

Section: Rhein Regulation On Other Signaling Pathwaysmentioning

confidence: 99%

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

et al. 2016

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Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few focus on the relationship of crosstalk among multiple pharmacological mechanisms. The mechanism of rhein involves multiple pathways which contain close interactions. From the overall perspective, the pathways which are related to the targets of rhein, are initiated by the membrane receptor. Then, MAPK and PI3K-AKT parallel signaling pathways are activated, and several downstream pathways are affected, thereby eventually regulating cell cycle and apoptosis. The therapeutic effect of rhein, as a multitarget molecule, is the synergistic and comprehensive result of the involvement of multiple pathways rather than the blocking or activation of a single signaling pathway. We review the pharmacological mechanisms of action of rhein by consulting literature published in the last 100 years in PubMed. We then summarize these pharmacological mechanisms from a comprehensive, interactive, and crosstalk perspective. In general, the molecular mechanism of action of drug must be understood from a systematic and holistic perspective, which can provide a theoretical basis for precise treatment and rational drug use.

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“…9 Cocrystals can also extend the market cycle of active pharmaceutical ingredient (API), endow natural products with patent and significantly reduce the cost of research and development. 10 Though forming cocrystals can greatly improve the nature of API, only one cocrystal has appeared so far on the market as medicine (glycine-theophylline cocrystal). 11 The probable reason may be that the purity of cocrystals is difficult to confirm and literature on the topic is scarce.…”

Section: Introductionmentioning

confidence: 99%

Fourier Transform Near-Infrared Spectroscopy Used for Purity Determination of Rhein-L-arginine Cocrystal (Argirein)

et al. 2013

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Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein

Abstract: Activated AQP4, endoplasmic reticulum stress and p66Shc were actively implicated in the inflammation and these were suppressed by argirein, and its activity is favorable due to synergism in combination with L-arginine.

Cited by 14 publications

References 42 publications

Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan‐Induced Paw Inflammation in Rats

Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan‐Induced Paw Inflammation in Rats

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

Fourier Transform Near-Infrared Spectroscopy Used for Purity Determination of Rhein-L-arginine Cocrystal (Argirein)

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