Activation of arginine vasopressin receptor 1a facilitates the induction of long-term potentiation in the accessory olfactory bulb of male mice

Namba, Toshiharu; Taniguchi, Masaru; Murata, Yuzo; Tong, Jia; Wang, Yujie; Okutani, Fumino; Yamaguchi, Masahiro; Kaba, Hideto

doi:10.1016/j.neulet.2016.09.056

Cited by 11 publications

(5 citation statements)

References 51 publications

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“…AVP can enhance social recognition, but most such studies involve AVP administration after interactions with an individual, and the effects, to our knowledge, have not been observed more than 24 h after administration ( 68 ). If acute VP increased how familiar the faces seemed, it could have, to the extent that increased familiarity increases subjective ratings, led to sustained enhancements in those responses, potentially through synaptic remodeling, which AVP can promote ( 69 – 71 ). Although it seems unlikely that a single administration of AVP would be sufficient to induce such alterations, it should be kept in mind that, despite AVP’s short half-life in tissue, the elevations observed in the brain after intranasal delivery were still apparent in the original studies by Born et al ( 17 ), with no signs of decreasing, 80 min after delivery, suggesting that intranasal AVP might, perhaps through feed-forward mechanism ( 72 ), trigger large and sustained elevations of AVP within the brain that could induce such changes.…”

Section: Discussionmentioning

confidence: 99%

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Rilling

Chen

et al. 2017

Front. Endocrinol.

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Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces. All subjects were also scanned a second time several days later with no treatment to evaluate the persistence of AVP effects over time. AVP acutely increased positive ratings of same-sex faces in women, with some evidence that these effects persisted until the second scan. While AVP had no acute effects on same-sex ratings in men, AVP increased positive ratings of same-sex faces several days later. On the other hand, AVP had no effect on other-sex face judgments in either sex. AVP modulation of brain function was focused on the nucleus accumbens (NAc) and the lateral septum, two reward processing areas involved in the formation of social bonds. AVP provoked acute increases in right NAc and bilateral lateral septum responses to female faces among men, with left lateral septum responses persisting over time while right NAc responses reversed over time. Finally, AVP modulated hypothalamic activation to faces in both men and women. The present study therefore indicates that intranasal AVP affects subjective ratings and neural responses to same and other-sex faces in men and women, with some effects persisting and others emerging over time. Future studies should investigate whether AVP effects are modulated by individual variables such as genotype, personality, or attachment style as previously reported for other nonapeptides.

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Section: Discussionmentioning

confidence: 99%

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Rilling

Chen

et al. 2017

Front. Endocrinol.

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“…The mechanisms through which either dose of intranasal AVP may produce prolonged negative and/or positive effects on face evaluations are entirely unclear. Acute elevations of AVP enhance social learning and memory processes in rodents, presumably by altering connectivity within neural networks ( 24 , 56 – 58 ). However, those influences are selective for specific individuals encountered immediately before AVP administration; in the current study, at least, AVP effects appeared to influence responses to faces seen after drug delivery and to generalize to new faces seen on subsequent days, which suggest an alternative mechanism that could involve lasting, general influences on social stimulus processing.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

et al. 2017

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Arginine vasopressin (AVP) and related peptides have diverse effects on social behaviors in vertebrates, sometimes promoting affiliative interactions and sometimes aggressive or antisocial responses. The type of influence, in at least some species, depends on social contexts, including the sex of the individuals in the interaction and/or on the levels of peptide within brain circuits that control the behaviors. To determine if AVP promotes different responses to same- and other-sex faces in men, and if those effects are dose dependent, we measured the effects of two doses of AVP on subjective ratings of male and female faces. We also tested if any influences persist beyond the time of drug delivery. When AVP was administered intranasally on an initial test day, 20 IU was associated with decreased social assessments relative to placebo and 40 IU, and some of the effects persisted beyond the initial drug delivery and appeared to generalize to novel faces on subsequent test days. In single men, those influences were most pronounced, but not exclusive, for male faces, whereas in coupled men they were primarily associated with responses to female faces. Similar influences were not observed if AVP was delivered after placebo on a second test day. In a preliminary analysis, the differences in social assessments observed between men who received 20 and 40 IU, which we suggest primarily reflect lowered social assessments induced by the lower dose, appeared most pronounced in subjects who carry what has been identified as a risk allele for the V1a receptor gene. Together, these results suggest that AVP’s effects on face processing, and possibly other social responses, differ according to dose, depend on relationship status, and may be more prolonged than previously recognized.

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“…However, vasopressin is also expressed by a large population of interneurons in the rat OB, where its action has been shown to be important for social recognition (Tobin et al, 2010). In recordings from acute brain slices, it has been shown that activation of the vasopressin receptor on GCs leads to dose-dependent long-term potentiation (Namba et al, 2016).…”

Section: Other Neuropeptidesmentioning

confidence: 99%

Signaling mechanisms underlying activity‐dependent integration of adult‐born neurons in the mouse olfactory bulb

Bao,

Romero,

Belfort

et al. 2024

Genesis

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SummaryAdult neurogenesis has fascinated the field of neuroscience for decades given the prospects of harnessing mechanisms that facilitate the rewiring and/or replacement of adult brain tissue. The subgranular zone of the hippocampus and the subventricular zone of the lateral ventricle are the two main areas in the brain that exhibit ongoing neurogenesis. Of these, adult‐born neurons within the olfactory bulb have proven to be a powerful model for studying circuit plasticity, providing a broad and accessible avenue into neuron development, migration, and continued circuit integration within adult brain tissue. This review focuses on some of the recognized molecular and signaling mechanisms underlying activity‐dependent adult‐born neuron development. Notably, olfactory activity and behavioral states contribute to adult‐born neuron plasticity through sensory and centrifugal inputs, in which calcium‐dependent transcriptional programs, local translation, and neuropeptide signaling play important roles. This review also highlights areas of needed continued investigation to better understand the remarkable phenomenon of adult‐born neuron integration.

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Activation of arginine vasopressin receptor 1a facilitates the induction of long-term potentiation in the accessory olfactory bulb of male mice

Cited by 11 publications

References 51 publications

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

Signaling mechanisms underlying activity‐dependent integration of adult‐born neurons in the mouse olfactory bulb

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