Activation of Cellular Oncogenes by Chemical Carcinogens in Syrian Hamster Embryo Fibroblasts

Abstract

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Activation of Cellular Oncogenes in Human Diploid Cell Strain (Kmb-13) Cells by Scooter Exhaust Particulate Matter Emissions

“…It is known that purified bacterially expressed p21 proteins when microinjected into cultured cells can stimulate DNA synthesis and induce transient morphologic transformation (Lacal et al, 1986). In SHE cells transformed by diethylstilbestrol, benzo[a]pyrene, or trenbolone, a significant elevation of the c-Ha-ras and c-myc expression was observed (Ebert et al, 1990). In BALB/c 3 T 3 cells transformed by glass fibers, c-Ha-ras oncogene was activated and exhibited malignant phenotype .…”