Activation of central sympathetic networks during innocuous and noxious somatosensory stimulation

Maihöfner, Christian; Seifert, F.; DeCol, Roberto

doi:10.1016/j.neuroimage.2010.11.061

Cited by 40 publications

(39 citation statements)

References 51 publications

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“…As discussed above, activity in both the perigenual ACC and mid-insula is associated with increased sympathetic activation (see also Critchley et al, 2003; Maihöfner et al, 2011). In our data, greater perigenual ACC activity was related to greater stress-induced release of AA (at an uncorrected threshold).…”

Section: Discussionmentioning

confidence: 85%

Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress

Rosenkranz

Esnault

Christian

et al. 2016

Brain, Behavior, and Immunity

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Background Psychological stress has long been recognized as a contributing factor to asthma symptom expression and disease progression. Yet, the neural mechanisms that underlie this relationship have been largely unexplored in research addressing the pathophysiology and management of asthma. Studies that have examined the mechanisms of this relationship in the periphery suggest that it is the superimposition of acute stress on top of chronic stress that is of greatest concern for airway inflammation. Methods We compared asthmatic individuals with high and low levels of chronic life stress in their neural and peripheral physiological responses to the Trier Social Stress Test and a matched control task. We used FDG-PET to measure neural activity during performance of the two tasks. We used both circulating and airway-specific markers of asthma-related inflammation to assess the impact of acute stress in these two groups. Results Asthmatics under chronic stress had a larger HPA-axis response to an acute stressor, which failed to show the suppressive effects on inflammatory markers observed in those with low chronic stress. Moreover, our PET data suggest that greater activity in the anterior insula during acute stress may reflect regulation of the effect of stress on inflammation. In contrast, greater activity in the mid-insula and perigenual anterior cingulate seems to reflect greater reactivity and was associated with greater airway inflammation, a more robust alpha amylase response, and a greater stress-induced increase in proinflammatory cytokine mRNA expression in airway cells. Conclusions Acute stress is associated with increases in markers of airway inflammation in asthmatics under chronic stress. This relationship may be mediated by interactions between the insula and anterior cingulate cortex, that determine the salience of environmental cues, as well as descending regulatory influence of inflammatory pathways in the periphery.

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Section: Discussionmentioning

confidence: 85%

Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress

Rosenkranz

Esnault

Christian

et al. 2016

Brain, Behavior, and Immunity

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“…Its widespread intra- and interstructural connections [5,15] are in line with its role in many neural processes, for instance related to autonomic control and interoception [16,17,18], gustation [19,20] somatosensation and pain [5,21,22,23,24] and valuation [14,25]. Mapping studies support a strong correlation between insular function and anatomy [26,27,28].…”

Section: Introductionmentioning

confidence: 96%

A Neuroimaging Strategy for the Three-Dimensional in vivo Anatomical Visualization and Characterization of Insular Gyri

Rosen

Chen

Hayes

et al. 2015

Stereotact Funct Neurosurg

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Background: Interest in the anatomy of the insula is driven by its multifunctionality and the need for accurate visualization for surgical purposes. Few in vivo studies of human insular anatomy have been conducted due to methodological and anatomical challenges. Objective: We used brain cortical morphometry tools to accurately reconstruct insular topology and permit a detailed visualization of its gyri in 3 dimensions. Methods: Sixty healthy subjects (33 females; 37.8 ± 12.8 years) underwent 3-tesla MRI scans. The strategy for characterizing the insula was: (1) create 3-dimensional (3-D) insula representations for visual analysis; (2) rate topological features using a gyral conspicuity index; (3) identify individual variations across subjects/between groups; (4) compare to prior findings. Results: Insular reconstruction was achieved in 113/120 cases. The anterior short, posterior short, anterior long gyri and central sulcus were easily identified. In contrast, middle short (MSG), posterior long (PLG) and accessory gyri (AG) were highly variable. The MSG, but not the PLG or AG, was clearer in males and in the left hemisphere, suggesting sex- and laterality-related differences. Conclusions: A noninvasive in vivo 3-D visualization strategy revealed anatomical variations of the insula in a healthy cohort. This methodological approach can be adopted for broad clinical and/or research purposes.

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“…4A -green curve) is very interesting because it may reflect the cortical effects of sympathetic involvement in neuropathic pain. 59 Because there were no significant stimulation threshold differences in both groups after standard electrical median and ulnar nerve stimulation at all stages of the measurements, threshold differences did not contribute to the cortical evoked magnetic responses. The CWP interindividual and intraindividual morphology differences of subjects and patients are supported by previous work.…”

Section: Modulated Cortical Processing In Neuropathic Painmentioning

confidence: 84%

Anesthetic Block of Pain-related Cortical Activity in Patients with Peripheral Nerve Injury Measured by Magnetoencephalography

et al. 2011

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Background: This study examined whether chronic neuropathic pain, modulated by a local anesthetic block, is associated with cortical magnetic field changes. Methods: In a group of 20 patients with pain caused by unilateral traumatic peripheral nerve injury, a local block with lidocaine 1% was administered and the cortical effects were measured and compared with a control group. The global field power (GFP), describing distribution of cortical activation after median and ulnar nerve stimulation, was plotted and calculated. The effects on the affected hemisphere and the unaffected hemisphere (UH) before and after a block of the injured nerve were statistically evaluated. Results: Major differences based on the GFP curves, at a component between 50 ms -90 ms (M70), were found in patients: in the affected hemisphere the M70 GFP peak values were statistically significantly larger in comparison with the UH, and the GFP curves differed morphologically. Interestingly, the mean UH responses were reduced in comparison with the control group, a finding suggesting that the UH is also part of the cortical changes. At M70, the GFP curves and values in the affected hemi-

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Activation of central sympathetic networks during innocuous and noxious somatosensory stimulation

Cited by 40 publications

References 51 publications

Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress

Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress

A Neuroimaging Strategy for the Three-Dimensional in vivo Anatomical Visualization and Characterization of Insular Gyri

Anesthetic Block of Pain-related Cortical Activity in Patients with Peripheral Nerve Injury Measured by Magnetoencephalography

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