Activation of cortical and striatal regions during the expression of a naturalistic compulsive-like behavior in the rabbit

Cano-Ramírez, Hugo; Hoffman, Kurt L.

doi:10.1016/j.bbr.2018.05.034

Cited by 7 publications

(2 citation statements)

References 57 publications

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“…More importantly, with regards of the present work, the long-term period induced a prominent hyperactive pattern in both gross (general motor activity in most tests) and fine-motor functions (increased nesting-behavior) that were correlated to hippocampal tau pathology (Muntsant and Giménez-Llort, 2020a ). Activation of cortical and striatal regions during the expression of a naturalistic compulsive-like behavior in the rabbit have been described (Cano-Ramírez and Hoffman, 2018 ), so these are also our target areas in our current investigations. Excessive nest building has been described as a unique behavioral phenotype in the deer mouse model of obsessive-compulsive disorder (Wolmarans et al, 2016 ).…”

Section: Discussionmentioning

confidence: 98%

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

Giménez‐Llort

Alveal-Mellado

2021

Front. Behav. Neurosci.

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The severity of this pandemic's scenarios will leave significant psychological traces in low resistant and resilient individuals. Increased incidence of depression, anxiety, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder has already been reported. The loss of human lives and the implementation of physical distance measures in the pandemic and post-COVID scenarios may have a greater impact on the elderly, mostly in those with dementia, as OCD and other neuropsychiatric symptoms (NPS) are quite prevalent in this population. Modeling NPS in animals relies in neuroethological perspectives since the response to new situations and traumatic events, critical for survival and adaptation to the environment, is strongly preserved in the phylogeny. In the laboratory, mice dig vigorously in deep bedding to bury food pellets or small objects they may find. This behavior, initially used to screen anxiolytic activity, was later proposed to model better meaningless repetitive and perseverative behaviors characteristic of OCD or autism spectrum disorders. Other authors found that digging can also be understood as part of the expression of the animals' general activity. In the present brief report, we studied the digging ethograms in 13-month-old non-transgenic and 3xTg-AD mice modeling normal aging and advanced Alzheimer's disease (AD), respectively. This genetic model presents AD-like cognitive dysfunction and NPS-like phenotype, with high mortality rates at this age, mostly in males. This allowed us to observe the digging pattern's disruption in a subgroup of 3xTg-AD mice that survived to their cage mates. Two digging paradigms involving different anxiogenic and contextual situations were used to investigate their behavior. The temporal course and intensity of digging were found to increase in those 3xTg-AD mice that had lost their “room partners” despite having lived in social structures since they were born. However, when tested under neophobia conditions, this behavior's incidence was low (delayed), and the temporal pattern was disrupted, suggesting worsening of this NPS-like profile. The outcomes showed that this combined behavioral paradigm unveiled distinct features of digging signatures that can be useful to study these perseverative behaviors and their interplay with anxiety states already present in the AD scenario and their worsening by naturalistic/forced isolation.

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Section: Discussionmentioning

confidence: 98%

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

Giménez‐Llort

Alveal-Mellado

2021

Front. Behav. Neurosci.

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“…Particularly high densities of OTR are found in the prefrontal cortex (PFC), medial preoptic area (MPOA), and LS 24 ; their abundance varies in relation to the female's reproductive state. These regions are involved in the regulation of nest‐building 25,26 and nursing 27 . Moreover, bilateral lesions of the paraventricular hypothalamic nucleus (PVN), particularly rich in OXT‐immunoreactive cells in lactating doe rabbits, 28 disrupt or abolish circadian nursing 29 .…”

Section: Introductionmentioning

confidence: 99%

Oxytocin antagonist does not disrupt rabbit maternal behavior despite binding to brain oxytocin receptors

Jiménez

Inoue

et al. 2023

J Neuroendocrinology

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We explored a possible role of oxytocin (OXT) for the onset and maintenance of rabbit maternal behavior by: (a) confirming that a selective oxytocin receptor antagonist (OTA) widely used in rodents selectively binds to OXT receptors (OXTR) in the rabbit brain and (b) determining the effect of daily intracerebroventricular (icv) injections of OTA to primiparous and multiparous does from gestation day 29 to lactation day 3. OTA efficiently displaced the high affinity, selective oxytocin receptor (OXTR) radioligand, 125I‐labeled ornithine vasotocin analog (125I‐OVTA), but was much less effective at displacing the selective V1a vasopressin receptor radioligand, 125I‐labeled linear vasopressin, thus showing high affinity and selectivity of OTA for rabbit OXTR as in rodents. Further, ICV OTA injections did not modify nest‐building, latency to enter the nest box, time spent nursing or the amount of milk produced, relative to vehicle‐injected does. The percentage of mothers suckling the litter was also similar between both groups, regardless of parity. Together, our results do not support a role of OXT for the initiation or maintenance of rabbit maternal behavior. Future studies are warranted to determine if OXT participates in fine‐tuning additional aspects of the maternal ethogram, for example, circadian periodicity of nursing and nest defense.

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Basic Protocols for the Study of Maternal Behavior in Rabbits

et al. 2023

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Activation of cortical and striatal regions during the expression of a naturalistic compulsive-like behavior in the rabbit

Cited by 7 publications

References 57 publications

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

Oxytocin antagonist does not disrupt rabbit maternal behavior despite binding to brain oxytocin receptors

Basic Protocols for the Study of Maternal Behavior in Rabbits

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