2009
DOI: 10.1155/2009/805709
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Activation of Cyclin‐Dependent Kinase 5 Is a Consequence of Cell Death

Abstract: Cyclin-dependent kinase 5 (Cdk5) is similar to other Cdks but is activated during cell differentiation and cell death rather than cell division. Since activation of Cdk5 has been reported in many situations leading to cell death, we attempted to determine if it was required for any form of cell death. We found that Cdk5 is activated during apoptotic deaths and that the activation can be detected even when the cells continue to secondary necrosis. This activation can occur in the absence of Bim, calpain, or neu… Show more

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Cited by 2 publications
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“…However, in the present research calpain seems not to play a prominent role in cell death, since calpeptin did not attenuate cell death or disrupt the B65 cell cycle. Similar results, in reference to calpain activation, were recently described by Ye and colleagues in C8 cells, where it was hypothesised that cdk5 activation is an early consequence of cell damage, and calpain inhibition did not prevent cell death after DNA damage [22]. Thus, our results suggest that in this model of DNA damage the formation of cdk5/p25 is a consequence of cell death or cdk5/p25 formation is not exclusively regulated by calpain.…”
Section: Discussionsupporting
confidence: 91%
“…However, in the present research calpain seems not to play a prominent role in cell death, since calpeptin did not attenuate cell death or disrupt the B65 cell cycle. Similar results, in reference to calpain activation, were recently described by Ye and colleagues in C8 cells, where it was hypothesised that cdk5 activation is an early consequence of cell damage, and calpain inhibition did not prevent cell death after DNA damage [22]. Thus, our results suggest that in this model of DNA damage the formation of cdk5/p25 is a consequence of cell death or cdk5/p25 formation is not exclusively regulated by calpain.…”
Section: Discussionsupporting
confidence: 91%