Activation of immediate early genes and memory formation

Tischmeyer, Wolfgang; Grimm, Rita

doi:10.1007/s000180050315

Cited by 382 publications

(301 citation statements)

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“…At 2 and 4 h after conditioning, mice were killed, hippocampi were removed, and total RNA was purified for conversion into cDNA (for details, see Materials and Methods). We examined the expression of the following genes: Egr1 (early growth response 1), Fos, Dusp1 (dual specificity phosphatase 1) Nr4a1, Jun,Icer,Nr4a3, , Bdnf4 (brain-derived neurotrophic factor, promoter 4), Dynorphin, Gadd45b (growth arrest and DNA-damageinducible 45 ␤), and Nrn1 (neuritin 1), which have all been shown to contain one or more CRE motifs and many of which are regulated by histone acetylation or involved in memory storage (Nedivi et al, 1996;Schmidt-Kastner et al, 1996;Tao et al, 1998;Tischmeyer and Grimm, 1999;Chen et al, 2002;Kida et al, 2002;Davis et al, 2003;Fass et al, 2003). Surprisingly, we found that, of these 12 genes, only Nr4a1 [also known as nur77 (nuclear receptor 77) and NGFI-B (nerve growth factor inducible-B)] had significantly increased expression 2 h after conditioning and administration of TSA (Table 1).…”

Section: Expression Of the Creb Target Genes Nr4a1 And Nr4a2 Are Selementioning

confidence: 99%

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey¹,

Hawk²,

Lattal³

et al. 2007

Journal of Neuroscience

770

761

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Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-binding protein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB-binding domain of CBP. Furthermore, we show that the HDAC inhibitor trichostatin A does not globally alter gene expression but instead increases the expression of specific genes during memory consolidation. Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex.

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Section: Expression Of the Creb Target Genes Nr4a1 And Nr4a2 Are Selementioning

confidence: 99%

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey¹,

Hawk²,

Lattal³

et al. 2007

Journal of Neuroscience

770

761

View full text Add to dashboard Cite

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“…The activity of other transcription factors, such as SRF, c-fos, egr1 or NF-κβ (Albensi and Mattson, 2000;Izquierdo and Cammarota, 2004;Ramanan et al, 2005;Tischmeyer and Grimm, 1999) can also promote de novo gene expression and support long-lasting changes in synaptic plasticity. The expression of some of these TFs, such as c-fos, egr1 or C/EBPβ, is itself induced during LTP formation and their activity can trigger a second wave of gene expression that may also be important for LTP consolidation.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Barco

Armentia

Alarcón

2008

Neuroscience & Biobehavioral Reviews

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Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited ten years later, Neuroscience and Biobehavioral Reviews (2008Reviews ( ), doi:10.1016Reviews ( /j.neubiorev.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d m a n u s c r i p t A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 2 Abstract A decade ago, the synaptic tagging hypothesis was proposed to explain how newly synthesized plasticity products can be specifically targeted to active synapses. A growing number of studies have validated the seminal findings that gave rise to this model, as well as contributed to unveil and expand the range of mechanisms underlying late-associativity and neuronal computation.Here, we will review what it was learnt during this past decade regarding the cellular and molecular mechanisms underlying synaptic tagging and synaptic capture. The accumulated experimental evidence has widened the theoretical framework set by the synaptic tagging and capture (STC) model and introduced concepts that were originally considered part of alternative models for explaining synapse-specific LTP. As a result, we believe that the STC model, now improved and expanded with these new ideas and concepts, still represents the most compelling hypothesis to explain late-associativity in synapse-specific plasticity processes. We will also discuss the impact of this model in our view of the integrative capability of neurons and associative learning. wordsKeywords: synaptic plasticity; LTP; associative learning; neuronal computation; synaptic tagging; synaptic capture; metaplasticity A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 3 Contents

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“…For a long time, the study of the brain mechanisms of birdsong focused on nuclei and pathways, which are collectively referred to as the "song system" (Nottebohm et al, 1990;Nottebohm, 1991Nottebohm, , 2000 (but see Bolhuis and Macphail, 2001;Bolhuis and EdaFujiwara 2003). However, analysis of the expression of immediate early genes (IEGs), a measure of neuronal activation (Sagar et al, 1988;Tischmeyer and Grimm, 1999;Davis et al, 2003), has revealed that other parts of the brain are involved in song perception. These brain regions include the caudomedial neostriatum (NCM) [also known as the caudomedial nidopallium (Reiner et al, 2004)] and the caudomedial hyperstriatum ventrale (CMHV) (or caudomedial mesopallium in the new nomenclature of Reiner et al, 2004) (Mello et al, 1992;Mello and Clayton, 1994;Jarvis and Nottebohm, 1997;Mello and Ribeiro, 1998;Bolhuis et al, 2000) (Fig.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of the Neural Representation of Birdsong Memory

Terpstra¹,

Bolhuis²,

Boer-Visser³

2004

J. Neurosci.

125

141

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Songbirds, such as zebra finches, learn their song from a tutor early in life. Forebrain nuclei in the "song system" are important for the acquisition and production of song. Brain regions [including the caudomedial part of the neostriatum (NCM) and of the hyperstriatum ventrale (CMHV)] outside the song system show increased neuronal activation, measured as expression of immediate early genes (IEGs), when zebra finch males are exposed to song. IEG expression in the NCM in response to tutor song is significantly positively correlated with the strength of song learning (i.e., the number of elements copied). Here, we exposed three groups of adult zebra finch males to tutor song, to their own song, or to novel conspecific song. The two control groups were included to examine an alternative explanation of our previous results in terms of variation in predisposed levels of attentiveness. Expression of Zenk, the protein product of the IEG ZENK, was measured in the NCM, CMHV, and hippocampus. There were no significant differences in overall Zenk expression between the three experimental groups. However, there was a significant positive correlation between Zenk expression in the NCM (but not in the other two regions) and strength of song learning in the males that were exposed to the tutor song. There was no such correlation in the other two groups. These results suggest that experience-related neuronal activation is specific to the tutor song and thus unlikely to be a result of differences in attention.

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Activation of immediate early genes and memory formation

Cited by 382 publications

References 126 publications

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

An Analysis of the Neural Representation of Birdsong Memory

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