Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: Analysis of immune cell populations and surface molecules

Ina, Yasuhiro; Sakai, Kazuo

doi:10.1080/09553000500519808

Cited by 81 publications

(43 citation statements)

References 27 publications

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“…Although previous studies by other authors suggest that T helper and T cytotoxic-suppressor cells have a similar radiosensitivity (9,19,34), our results reveal that the responses induced by different mitogens, which are specific of T cells, differ in terms of their radiosensitivity. Thus it can be appreciated that PHA-induced proliferation is more radiosensitive than that induced by ConA, irrespectively of the dose considered; other works have obtained similar results (1,18,22).…”

Section: Discussioncontrasting

confidence: 53%

Efecto de la irradiación-γ in vitro sobre la respuesta mitogénica de linfocitos de ratón

2008

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The objective of this study was to analyze the proliferative response of BALB/c mice lymphocytes after in vitro irradiation (0.05 to 6 Gy). The capability of irradiated lymphocytes for proliferating without any stimulation and after activation with specific T and B cell mitogens has been evaluated. The results show that ionizing radiation significantly inhibits spontaneous cellular proliferation and that induced by mitogens and that variations in the degree of inhibition are found depending on the inducing proliferation mitogens and the dosage applied. The conclusion drawn is that different lymphocyte populations have different radiosensitivities, being B cells more sensitive to ionizing irradiation than T cells. Besides, the effects of gamma-irradiation vary according to the different subpopulations of T cells or, alternatively, to different T-dependent activation mechanisms.

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Section: Discussioncontrasting

confidence: 53%

Efecto de la irradiación-γ in vitro sobre la respuesta mitogénica de linfocitos de ratón

2008

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“…It has been proposed from the published data that mammalian cells have the physiological capacity to protect themselves constantly by preventing and repairing DNA damage. Furthermore, damaged cells are susceptible to removal by apoptosis or the immune system and chronic low-dose-rate radiation activate the immune system of the whole body 26 . Low-dose radiation was suggested to induce cellular signaling that may stimulate cellular protection systems over hours to weeks.…”

Section: The Hormesis Theorymentioning

confidence: 99%

Hormesis in Carcinogenicity of Non-genotoxic Carcinogens

et al. 2006

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Abstract:Recently the idea of hormesis, a biphasic dose-response relationship in which a chemical exerts opposite effects dependent on the dose, has attracted interest in the field of carcinogenesis. With non-genotoxic agents there is considerable experimental evidence in support of hormesis and the present review highlights current knowledge of doseresponse effects. In particular, several in vivo studies have provided support for the idea that non-genotoxic carcinogens may inhibit hepatocarcinogenesis at low doses. Here, we survey the examples and discuss possible mechanisms of hormesis with cytochrome P450 inducers, such as phenobarbital, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), α-benzene hexachloride (α-BHC), and other non-genotoxins. Epigenetic processes differentially can be affected by agents that impinge on oxidative stress, DNA repair, cell proliferation, apoptosis, intracellular communication and cell signaling. Non-genotoxic carcinogens may target nuclear receptors, cause aberrant DNA methylation at the genomic level and induce post-translational modifications at the protein level, thereby impacting on the stability or activity of key regulatory proteins, including oncoproteins and tumor suppressor proteins. Via multiple epigenetic lesions, nongenotoxic carcinogens can elicit a variety of changes contributing to cellular carcinogenesis. (J Toxicol Pathol 2006; 19: 111-122)

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“…A number of factors may explain why the consistent characterization of immune responses to radiation remains elusive including differences in radiosensitivity or reactivity of different cell and tissue types, and dose-dependent effects. The latter have been explored in a number of studies, some of which suggest that lower doses of radiation have a greater potential to enhance immune responses (Hashimoto et al, 1999;Cao et al, 2002;Ina and Sakai, 2005;Shigematsu et al, 2007).…”

Section: Revisiting the Role Of Radiationmentioning

confidence: 99%

Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer

Roses

Koski

et al. 2008

Oncogene

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Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: Analysis of immune cell populations and surface molecules

Abstract: Chronic low-dose-rate radiation activated the immune system of the whole body.

Cited by 81 publications

References 27 publications

Efecto de la irradiación-γ in vitro sobre la respuesta mitogénica de linfocitos de ratón

Efecto de la irradiación-γ in vitro sobre la respuesta mitogénica de linfocitos de ratón

Hormesis in Carcinogenicity of Non-genotoxic Carcinogens

Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer

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