2021
DOI: 10.1016/j.neuropharm.2021.108797
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Activation of locus coeruleus to rostromedial tegmental nucleus (RMTg) noradrenergic pathway blunts binge-like ethanol drinking and induces aversive responses in mice

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Cited by 28 publications
(18 citation statements)
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“…Previous work has shown binge drinking alters glutamate receptor function across many brain regions (Hwa, Besheer, and Kash 2017). Only a few neural circuits, such as the ventral tegmental area and thalamic inputs to the extended amygdala, locus coeruleus outputs to lateral hypothalamus and rostromedial tegmental nucleus, and medial prefrontal cortex inputs to the periaqueductal gray have been directly linked to the behavioral control of binge alcohol drinking (Rinker et al 2017;Ferguson et al 2019;Levine et al 2021;Dornellas et al 2021;Burnham et al 2021;Siciliano et al 2019). The insular cortex is an interoceptive brain region that regulates many components of drug use and is implicated in AUD (Centanni et al 2021;Gogolla 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Previous work has shown binge drinking alters glutamate receptor function across many brain regions (Hwa, Besheer, and Kash 2017). Only a few neural circuits, such as the ventral tegmental area and thalamic inputs to the extended amygdala, locus coeruleus outputs to lateral hypothalamus and rostromedial tegmental nucleus, and medial prefrontal cortex inputs to the periaqueductal gray have been directly linked to the behavioral control of binge alcohol drinking (Rinker et al 2017;Ferguson et al 2019;Levine et al 2021;Dornellas et al 2021;Burnham et al 2021;Siciliano et al 2019). The insular cortex is an interoceptive brain region that regulates many components of drug use and is implicated in AUD (Centanni et al 2021;Gogolla 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, chemogenetic silencing of this pathway selectively modulated binge-like ethanol intake and did not alter the consumption of sucrose, another salient reinforcer that entails calories like ethanol. Given the role of the LHb in modulating the aversive properties of ethanol and ethanol withdrawal, future work will determine if this circuit is involved in modulating the aversive properties of ethanol by examining if silencing this pathway augments ethanol-induced conditioned taste aversions or unconditioned aversive responses [ 54 ]. The present results suggest that blunting GABAergic tone in LHb-projecting CeA neurons may represent a new approach to preventing the development of AUDs, and that drugs that target NPY Y1Rs are potential attractive targets.…”
Section: Discussionmentioning
confidence: 99%
“…Using cell-type-specific retrograde trans-synaptic rabies virus tracing techniques, we found that RMTg GABAergic neurons receive wide projections in the brain, including dense projections from the LH, zona incerta, and LHb. Moreover, several brain regions, such as the PAG, DR, and LC, which contain a large number of REM-off neurons, also send inputs to RMTg GABAergic neurons 3 , 78 , 79 . Therefore, more research is needed on which emotional or physiological factors or which input circuit is implicated in the activation of RMTg GABAergic neurons to regulate sleep.…”
Section: Discussionmentioning
confidence: 99%