Activation of macrophages by the ophiopogon polysaccharide liposome from the root tuber of Ophiopogon japonicus

Sun, Wenjing; Hu, Wenjie; Meng, Kai; Yang, Lumiao; Zhang, Weimin; Song, Xiaoping; Qu, Xiaohao; Zhang, Yueyang; Ma, Lin

doi:10.1016/j.ijbiomac.2016.06.037

Cited by 33 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages can bind to plant-derived polysaccharides and/or glycoproteins by Toll-like receptor 4 (TLR4), CD14, complement receptor 3 (CR3), scavenger receptor (SR), mannose receptor (MR), and Dectin-1. The activation of macrophage receptors can initiate a series of intracellular signaling cascades, leading to the transcriptional activation and production of inflammation-related cytokines (56–60), as shown in the Figure 1 (35).…”

Section: Mechanism Of Immunoregulation By Plant Polysaccharidesmentioning

confidence: 99%

Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides

2019

View full text Add to dashboard Cite

Polysaccharides are among the most important members of the biopolymer family. They are natural macromolecules composed of monosaccharides. To date, more than 300 kinds of natural polysaccharide compounds have been identified. They are present in plants, animals, and microorganisms, and they engage in a variety of physiological functions. In the 1950s, due to the discovery of their immunoregulatory and anti-tumor activities, polysaccharides became a popular topic of research in pharmacology, especially in immunopharmacology. Plants are an important source of natural polysaccharides. Pharmacological and clinical studies have shown that plant polysaccharides have many functions, such as immune regulation, anti-tumor activity, anti-inflammatory activity, anti-viral functions, anti-radiation functions, and a hypoglycaemic effect. The immunomodulatory effects of plant polysaccharides have received much attention. Polysaccharides with these effects are also referred to as biological response modifiers (BRMs), and research on them is one of the most active areas of polysaccharide research. Thus, we summarize immunomodulatory effects of botanical polysaccharides isolated from different species of plants on the macrophage. The primary effect of botanical polysaccharides is to enhance and/or activate macrophage immune responses, including increasing reactive oxygen species (ROS) production, and enhancing secretion of cytokines and chemokines. Therefore, it is believed that botanical polysaccharides have significant therapeutic potential, and represent a new method for discovery and development of novel immunomodulatory medicine.

show abstract

Section: Mechanism Of Immunoregulation By Plant Polysaccharidesmentioning

confidence: 99%

Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides

2019

View full text Add to dashboard Cite

show abstract

“…IFN-γ is the first line of defense against antiviral infection, especially it plays a crucial role in cellular immunity ( 44 ). As a key multifunctional cytokine, IL-1β is involved in both autoimmune inflammatory responses and a range of cellular activities, such as cell proliferation, differentiation, and apoptosis ( 45 , 46 ). Produced by activated monocytes, fibroblasts, endothelial cells, and so on, IL-6 can stimulate lymphocytes proliferation and promote the production of immunoglobulin by B cells ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Lian

et al. 2022

Front. Vet. Sci.

Self Cite

View full text Add to dashboard Cite

This study was designed to systematically elucidate the immunomodulatory and antioxidant effects of three polysaccharide fractions (ACP60, ACP80, and ACPt2) from Abrus cantoniensis on cyclophosphamide (CTX)-induced immunosuppressive mice. The experimental mice were divided into 12 groups, then modeled and administrated with different doses of three polysaccharides (50, 150, 300 mg/kg/day) by gavage. The results showed that ACP could markedly recover the CTX-induced decline in immune organ and hemocytes indexes and promote proliferation of splenocytes, earlap swelling rate, secretion of cytokines (TNF-α, IFN-γ, IL-1β, IL-6), and immunoglobulin (Ig-M and Ig-G). Additionally, ACP improved the enzymatic activities of T-SOD and GSH-PX greatly, while the level of MDA was significantly decreased in the liver. In particular, ACPt2 had higher immunomodulatory and antioxidant activities than ACP60 and ACP80. Based on the present findings, ACP could be utilized as an efficacious candidate for immunomodulators and antioxidants, which provide a new application prospect in the food and pharmaceutical industries.

show abstract

“…Radix Liriopes, one of the dominant drugs, was ascertained to have antioxidative and anti-inflammatory activities. 19 , 20 Multiple in vitro studies demonstrate that ruscogenin, the major constituent of Radix Liriopes, had a significant anti-inflammatory effect by inhibiting proinflammatory cytokine (eg, tumor necrosis factor–α [TNF-α], interleukin-6 [IL-6], and IL-1) overexpression and suppressed nuclear factor–κB (NF-κB) activation. 21 A plethora of evidence also shows that Scutellaria baicalensis inhibits the production of inflammatory cytokines (eg, TNF-α, IL-6) by negatively regulating the NF-κB signaling pathway under LPS simulation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Traditional Chinese Medicine in Treatment and Prophylaxis of Radiation-Induced Oral Mucositis in Patients Receiving Radiotherapy: A Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

Objective: To estimate the efficacy of traditional Chinese medicine (Chining decoction, CHIN) for radiation-induced oral mucositis in patients with head and neck cancer. Methods: From May 2014 to December 2015, 70 consecutive patients were randomly assigned to receive CHIN (treatment group) or recombinant human epidermal growth factor (rhEGF) spray (control group) at a 1:1 ratio. CHIN was administered to treatment group from the first day of radiotherapy until the completion of radiotherapy. Simultaneously, the rhEGF spray was administered to control group on the oral mucosa of irradiated area. The clinical benefit was determined by gradation of mucositis (Common Terminology Criteria for Adverse Events v4.0), oral pain, and xerostomia (visual analysis scale) for each week during radiotherapy. Body mass index was evaluated before and after radiotherapy. Results: Patients in the treatment group had prominent remission of oral pain and grade of mucositis on each observing point compared with those in control group (P < .01). Xerostomia was decreased notably in treatment group compared with control group (P < .01). Body mass index in the treatment group exhibited advantage over control group after radiotherapy, but there was no statistical significance (19.8 ± 3.26 vs 18.8 ± 2.5 kg/m2, P = .153, >.05). Conclusions: CHIN presented an obvious advantage in preventing radiation-induced oral mucositis compared with rhEGF spray.

show abstract

Activation of macrophages by the ophiopogon polysaccharide liposome from the root tuber of Ophiopogon japonicus

Cited by 33 publications

References 28 publications

Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides

Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Efficacy of Traditional Chinese Medicine in Treatment and Prophylaxis of Radiation-Induced Oral Mucositis in Patients Receiving Radiotherapy: A Randomized Controlled Trial

Contact Info

Product

Resources

About