2007
DOI: 10.1152/jn.00171.2007
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Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys

Abstract: Kliem MA, Maidment NT, Ackerson LC, Chen S, Smith Y, Wichmann T. Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys. J Neurophysiol 98: 1489-1500, 2007. First published July 18, 2007; doi:10.1152/jn.00171.2007. Studies of the effects of dopamine in the basal ganglia have focused on the striatum, whereas the functions of dopamine released in the internal pallidal segment (GPi) or in the substantia nigra pars reticulata (SNr) have received less attention. Anat… Show more

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Cited by 67 publications
(88 citation statements)
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“…The expression of DAT may decrease following GDNF, 42 and modulation of DA-D 1 receptor function in SN affects basal ganglia function 43,44 and open-field locomotion. 45 DA-D 1 receptor expression was not significantly different in the SN (Figure 7A), striatum (Figure 7B), or NAc (Figure 7D).…”
Section: Resultsmentioning
confidence: 99%
“…The expression of DAT may decrease following GDNF, 42 and modulation of DA-D 1 receptor function in SN affects basal ganglia function 43,44 and open-field locomotion. 45 DA-D 1 receptor expression was not significantly different in the SN (Figure 7A), striatum (Figure 7B), or NAc (Figure 7D).…”
Section: Resultsmentioning
confidence: 99%
“…SN and GPi showed some differences in the CC (Figures 6I,K) and in the Pearson and Spearman correlations (Figure 3) with S1 and M1 (negative relationships for the SN and no significant linking for GPi), suggesting a different functional connectivity of GPi and SN with the somatosensory and motor cortex. Although GPi and SN are frequently considered as a single entity in BG models (Albin et al, 1989; Alexander and Crutcher, 1990; Delong, 1990; Tanibuchi et al, 2009), there are biochemical (Windels et al, 2000; Kliem et al, 2007, 2010), odological (Deniau et al, 1982; Nakanishi et al, 1991; Parent et al, 1999; Mailly et al, 2003), and electrophysiological (Wichmann et al, 1999; Kaneda et al, 2005; Kliem et al, 2010; Lafreniere-Roula et al, 2010) data suggesting functional differences between them (Chastan et al, 2009; Nambu, 2011). …”
Section: Discussionmentioning
confidence: 99%
“…An example to illustrate the last point is that many basal ganglia neurons and circuits autonomously produce oscillatory firing patterns due to intrinsic membrane properties. Furthermore, the simple models do not take into account more recent anatomical findings, such as the influence of thalamostriatal projections [30], extrastriatal actions of dopamine (e.g., [31]), or brain stem projections of the basal ganglia [32]. …”
Section: Connections Between Basal Ganglia Nucleimentioning
confidence: 99%