Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

Weijzen, Sanne; Rizzo, Paola; Braid, Mike; Vaishnav, Radhika A.; Jonkheer, Suzanne; Zlobin, Andrei; Osborne, Barbara A.; Gottipati, Sridevi; Aster, Jon C.; Hahn, William C.; Rudolf, Michael P.; Siziopikou, Kalliopi P.; Kast, W. Martin; Miele, Lucio

doi:10.1038/nm754

Cited by 497 publications

(430 citation statements)

References 44 publications

Supporting

Mentioning

406

Contrasting

Unclassified

Order By: Relevance

“…23 BxPC-3 cells were transfected with Notch-1 siRNA and siRNA control, respectively, using Lipofectamine 2000. BxPC-3 cells were stably transfected with human Notch-1 ICN or vector alone (pcDNA3) and maintained under neomycin selection.…”

Section: Plasmids and Transfectionsmentioning

confidence: 99%

Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells

Wang

Zhang

Banerjee

et al. 2005

Intl Journal of Cancer

120

View full text Add to dashboard Cite

This article has been retracted at the request of: Editor‐in‐Chief and Author ‘Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells’, by Wang, Z., Zhang, Y., Banerjee, S., Li, Y. and Sarkar, F. H. The above article and associated erratum, published online on 11 November 2005 and 6 February 2014, respectively, in Wiley Online Library (http://wileyonlinelibrary.com), have been retracted by agreement between the authors, the journal Editor‐in‐Chief, Professor Peter Lichter, and Wiley Periodicals, Inc. In addition to what was corrected in the erratum, a university investigation involving the first and the corresponding author determined that several figures in this paper were re‐used, mislabeled, manipulated, or duplicated while processing/compiling the final figures assembled from the original data sources. Therefore, the authors are retracting the paper in its entirety although they maintain that these issues did not affect the major conclusions. They apologize for any inconvenience this may have caused. Reference Wang, Z., Zhang, Y., Banerjee, S., Li, Y. and Sarkar, F. H. (2006), Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells. Int. J. Cancer, 118:1930–1936. doi:10.1002/ijc.21589; corrected by Erratum: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells. Int. J. Cancer, 134: E3. doi: .

show abstract

Section: Plasmids and Transfectionsmentioning

confidence: 99%

Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells

Wang

Zhang

Banerjee

et al. 2005

Intl Journal of Cancer

120

View full text Add to dashboard Cite

show abstract

“…For example, in T-cell leukaemia it was shown that Notch-induced transformation required the activation of MAP kinase and PI-3 kinase activity (Fitzgerald et al, 2000). Conversely, it was shown that activation of Notch signalling was an obligate step in Ras-induced transformation in an experimental system using human fibroblasts (Weijzen et al, 2002). However, we only detected very modest activation of the ERK pathway upon VPA treatment (data not shown).…”

Section: Discussionmentioning

confidence: 62%

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

et al. 2005

View full text Add to dashboard Cite

Neuroblastoma (NB), a sympathetically derived childhood tumour, shows characteristics of neuronal precursor cells, suggesting a halted differentiation process. We have previously shown that the Notch signalling cascade, a key player during normal neurogenesis, also might be involved in NB differentiation. Valproic acid (VPA), a well-tolerated antiepileptic drug, has been shown to induce differentiation and cell death of NB cells, possibly associated with its recently described HDAC inhibiting activity. Stimulation of NB cells with VPA led to increased cell death and phenotypic changes associated with differentiation, that is, neurite extension and upregulation of neuronal markers. VPA treatment also led to an activated Notch signalling cascade as shown by increased levels of intracellular Notch-1 and Hes-1, mimicking the initial phase of induced differentiation. These results reinforce that VPA potentially could be used in differentiation therapy of NB and that the effects in part could be a consequence of interference with the Notch signalling cascade.

show abstract

“…Abundant evidence indicates that Notch1 is involved in the angiogenesis and tumorigenesis of various types of malignancy. It has been revealed previously that Notch1 signaling is the convergence point of numerous signaling pathways (23). The dysfunction of Notch1 may inhibit cell differentiation, resulting in the malignant transformation of undifferentiated cells.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes

2017

View full text Add to dashboard Cite

Abstract. Pituitary adenoma (PA) is a common type of benign tumor of the pituitary gland that is characterized by specific signs and symptoms, primarily associated with hypersecretion of pituitary glycoprotein hormones (thyroid-stimulating, growth and adrenocorticotrophic hormones, and prolactin). Surgery is the first-line treatment, although postoperative residual tissues/cells and subsequent recurrence remain notable complications. Gene therapy is an effective approach for treatment, as previous studies have demonstrated that the Notch signaling pathway participates in the pathogenesis of PA. The focus of the present study was on the associations between the expression of the Notch1 receptor and its ligands δ-like canonical Notch ligand (Dll) 1, Dll3 and Dll4 in patients with PA. Using reverse transcription-quantitative polymerase chain reaction and western blot analyses, to the best of our knowledge, this is the first study to provide a description of the differential expression of the Notch1 receptor and its ligands Dll1, Dll3, and Dll4 in various types of human PA at the mRNA and protein levels. The results of the present study demonstrated that Notch1 protein expression was positively correlated with Dll4 protein expression, but negatively correlated with Dll3 protein expression, indicating synergistic effects between the Notch1 receptor and Dll4 ligand. Furthermore, the Dll3 ligand may be an inhibitor of the Notch1 receptor, indicating an antagonistic association between Notch1 and the Dll3 ligand. These results have identified a potential target for the treatment of patients with PA.

show abstract

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

Cited by 497 publications

References 44 publications

Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells

Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes

Contact Info

Product

Resources

About