Activation of NPY receptor subtype 1 by [D-His26]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD

Nwokafor, Chiso; Serova, Lidia; Nahvi, Roxanna J.; McCloskey, Jaclyn; Sabban, Esther L.

doi:10.1016/j.npep.2019.102001

Cited by 24 publications

(19 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, HDAC activity impairment can lead to an increase in the NPY expression in the central nucleus of amygdala and medial nucleus of amygdala [15]. NPY is a hypothalamic orexigenic neuropeptide which is sufficient to prevent anxiety, social disorders and depressive symptoms [16]. Besides that, NPY and its receptors have been evidenced to impose anti-inflammatory and antidepressant effects on lipopolysaccharidesinduced depression rat models [17].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: HDAC1-Mediated MicroRNA-124-5p Regulates NPY to Affect Learning and Memory Abilities in Rats with Depression

Tang

2021

Nanoscale Res Lett

View full text Add to dashboard Cite

Researches pivoting on histone deacetylases (HDACs) in depression have been excessively conducted, but not much on HDAC1. Therein, the present study is launched to disclose the mechanism of HDAC1/microRNA (miR)-124-5p/neuropeptide Y (NPY) axis in depression. Sprague Dawley rats were stimulated by chronic unpredictable mild stress to establish depression models. Depressed rats were injected with inhibited HDAC1 or suppressed miR-124-5p to explore their roles in body weight, learning and memory abilities, oxidative stress and inflammation in serum and neurotransmitter expression in hippocampal tissues. MiR-124-5p, HDAC1 and NPY expression in the hippocampus were tested. The interactions of miR-124-5p, HDAC1 and NPY expression were also confirmed. Higher miR-124-5p and HDAC1 and lower NPY expression levels were found in the hippocampus of depressed rats. Inhibited miR-124-5p or suppressed HDAC1 attenuated learning and memory abilities and increased body weight of depressed rats. Knockdown of miR-124-5p or inhibition of HDAC1 suppressed oxidative stress and inflammation and promoted neurotransmitter expression of depressed rats. HDAC1 mediated miR-124-5p to regulate NPY. Knockdown of NPY abolished the protective effects of inhibited miR-124-5p on depressed rats. Our study illustrates that suppression of either miR-124-5p or HDAC1 up-regulates NPY to improve memory and learning abilities in depressed mice, which may update the existed knowledge of depression and provide a novel reference for treatment of depression.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: HDAC1-Mediated MicroRNA-124-5p Regulates NPY to Affect Learning and Memory Abilities in Rats with Depression

Tang

2021

Nanoscale Res Lett

View full text Add to dashboard Cite

show abstract

“…In rodents, the alleviation of anxiety caused by overexpression of Y1R also corroborates the above findings ( 131 ). Similarly, knockout of Y1R leads to anxiety outcomes ( 132 ), and the intranasal administration of Y1R agonists is sufficient to prevent anxiety ( 133 ). Moreover, specific Y5R agonists were injected into the PVN, resulting in a reduction in anxiety-related behaviors in animals ( 134 ).…”

Section: Npy Indirectly Regulates the Immune Responsementioning

confidence: 99%

“…However, NPY expression in the brain decreases overall during depression ( 13 ). Consequently, intraventricular infusion of NPY or intranasal delivery of NPY to the brain effectively prevents depressive behavior in animal models ( 133 , 141 ). LP-NPY (Y1R and Y5R agonists) is as useful as NPY and presents therapeutic potential in preventing the development of depressive-like behavior ( 142 ).…”

Section: Npy Indirectly Regulates the Immune Responsementioning

confidence: 99%

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Chen

Liu

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in regulating a variety of biological processes, including food intake, energy metabolism, and emotional expression. However, emerging evidence points to NPY also as a critical transmitter between the nervous system and immune system, as well as a mediator produced and released by immune cells. In vivo and in vitro studies based on gene-editing techniques and specific NPY receptor agonists and antagonists have demonstrated that NPY is responsible for multifarious direct modulations on immune cells by acting on NPY receptors. Moreover, via the central or peripheral nervous system, NPY is closely connected to body temperature regulation, obesity development, glucose metabolism, and emotional expression, which are all immunomodulatory factors for the immune system. In this review, we focus on the direct role of NPY in immune cells and particularly discuss its indirect impact on the immune response.

show abstract

“…Selective agonist or antagonists of the NPY receptor subtypes have been shown to modulate behaviors associated with stress-disorders. For example, selective agonism of Y1R has been reported to mediate the anxiolytic and anti-depressive effects of NPY [ 38 , 39 , 40 ]. Whereas, Y1R and Y2R appear to regulate responses to conditioned fear [ 41 ].…”

Section: Stress-protective Effects Of Npymentioning

confidence: 99%

Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders

Nahvi

Sabban

2020

Biomolecules

Self Cite

View full text Add to dashboard Cite

The neuropeptide Y (NPY) system is emerging as a promising therapeutic target for neuropsychiatric disorders by intranasal delivery to the brain. However, the vast majority of underlying research has been performed with males despite females being twice as susceptible to many stress-triggered disorders such as posttraumatic stress disorder, depression, anorexia nervosa, and anxiety disorders. Here, we review sex differences in the NPY system in basal and stressed conditions and how it relates to varied susceptibility to stress-related disorders. The majority of studies demonstrate that NPY expression in many brain areas under basal, unstressed conditions is lower in females than in males. This could put them at a disadvantage in dealing with stress. Knock out animals and Flinders genetic models show that NPY is important for attenuating depression in both sexes, while its effects on anxiety appear more pronounced in males. In females, NPY expression after exposure to stress may depend on age, timing, and nature and duration of the stressors and may be especially pronounced in the catecholaminergic systems. Furthermore, alterations in NPY receptor expression and affinity may contribute to the sex differences in the NPY system. Overall, the review highlights the important role of NPY and sex differences in manifestation of neuropsychiatric disorders.

show abstract

Activation of NPY receptor subtype 1 by [D-His26]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD

Cited by 24 publications

References 69 publications

RETRACTED ARTICLE: HDAC1-Mediated MicroRNA-124-5p Regulates NPY to Affect Learning and Memory Abilities in Rats with Depression

RETRACTED ARTICLE: HDAC1-Mediated MicroRNA-124-5p Regulates NPY to Affect Learning and Memory Abilities in Rats with Depression

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders

Contact Info

Product

Resources

About