Activation of Nrf-2 Transcription Factor and Caspase Pathway with Royal Jelly Reduces Fluoride Induced Testicular Damage and Infertility in Rats

Oral administration of proniosomal glibenclamide formulation protects testicular tissue from hyperglycemia fluctuations and ROS via Nrf2/HO-1 pathway

“…While the reproductive system requires ROS for reproduction, the risk posed by an uncontrolled generation by stimulating the physiologically antioxidative systems when needed [ 50 ]. The antioxidation system gets stimulated by Nrf2, which plays an important role in stimulating antioxidant enzymes through the ARE [ 51 ]. However, if Nrf2 activity is impaired, oxidative stress and inflammation accumulate.…”