2009
DOI: 10.1016/j.npep.2009.04.006
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Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat

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Cited by 52 publications
(37 citation statements)
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“…The main finding of this study was that exogenous The arousal-promoting action of the orexin system in the central nervous system (CNS) by activation of multiple subcortical arousal systems including the basal forebrain [28] , tuberomammillary nucleus [23,29] and locus coeruleus [30] has been well documented. In this study, we found that enhancement of wakefulness in rats was induced by microinjection of orexin A into the lateral hypothalamus where these orexin neurons are located.…”
Section: Discussionmentioning
confidence: 98%
“…The main finding of this study was that exogenous The arousal-promoting action of the orexin system in the central nervous system (CNS) by activation of multiple subcortical arousal systems including the basal forebrain [28] , tuberomammillary nucleus [23,29] and locus coeruleus [30] has been well documented. In this study, we found that enhancement of wakefulness in rats was induced by microinjection of orexin A into the lateral hypothalamus where these orexin neurons are located.…”
Section: Discussionmentioning
confidence: 98%
“…It has been reported that orexinergic neurons participate in the control of rapid eye movement (REM) sleep and the orexin-1 receptor is particularly necessary in the suppression of REM sleep [5]. Our earlier studies demonstrated that activation of the orexinergic signals in the basal forebrain significantly increased acetylcholine efflux in the somatosensory cortical region and shortened the awakening time of rats under inhalation or intravenous anesthesia [6]. These findings strongly supported the notion that orexinergic neurons might play a crucial role in the regulation of postanesthesia arousal.It has been reported that the anesthesia behaviors of rats change after SD in terms of time of reduced loss of righting reflex (LORR) and delayed recovery of the righting reflex (RORR) [7].…”
mentioning
confidence: 97%
“…5 Recently, we demonstrated that orexinergic signals are involved in regulation of the anesthesia-awake cycle. 6,7 It is also well known that various physiologies, including sleep patterns, 8,9 energy homeostasis, 10 autonomic functions, and neuroendocrine functions 11,12 are often abnormal in patients with stroke. These phenomena inspired us to speculate that there is a correlation between the orexin system and cerebral ischemic injury.…”
mentioning
confidence: 99%