2002
DOI: 10.1128/jvi.76.4.1559-1568.2002
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Activation of p38 and ERK Signaling during Adenovirus Vector Cell Entry Lead to Expression of the C-X-C Chemokine IP-10

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Cited by 118 publications
(136 citation statements)
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“…The events involved in virus entry into a cell activate a number of second messenger pathways and signaling molecules. Downstream effects of signaling include the induction of adhesion molecules and multiple chemokines such as RANTES, IP-10, MIP-2, MCP-1 (32,33). In the current cardiac transplant model, the adenovirus vector induced multiple potent chemokines in transduced grafts, with IP-10 induced as early as day 1; MCP-1, MIP-1a, MIP-2 on day 3, and many more chemokines by day 7.…”
Section: Discussionmentioning
confidence: 89%
“…The events involved in virus entry into a cell activate a number of second messenger pathways and signaling molecules. Downstream effects of signaling include the induction of adhesion molecules and multiple chemokines such as RANTES, IP-10, MIP-2, MCP-1 (32,33). In the current cardiac transplant model, the adenovirus vector induced multiple potent chemokines in transduced grafts, with IP-10 induced as early as day 1; MCP-1, MIP-1a, MIP-2 on day 3, and many more chemokines by day 7.…”
Section: Discussionmentioning
confidence: 89%
“…20 The very rapid increase in cytokine secretion and fever makes viral protein expression an unlikely explanation for these responses. Similar very rapid increases in the levels of mRNA for IL-8, and stimulation of signal transduction pathways, [24][25][26][27][28] suggest that the earliest phase (1-2 h) of inflammatory response to adenoviral vectors, both in nervous tissue as well as in other tissues, is independent of viral vector expression. Thus, the adenoviral capsid on its own may cause, through direct interactions at the membrane of target cells, stimulation of pro-inflammatory signalling cascades resulting in cytokine release.…”
Section: Brain Inflammation Upon Injection Of Viral Vectorsmentioning
confidence: 99%
“…The underlying reasons for this will require further investigation, but it is possible that the ability of adenovirus type-5 vectors to elicit potent innate immune responses and local inflammatory reactions, which are essential in initiating primary immune responses, plays a role in this process [64][65][66].…”
Section: Discussionmentioning
confidence: 99%