Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots

Evtugina, Natalia G.; Peshkova, Alina D.; Khabirova, Alina I.; Andrianova, Izabella A.; Abdullayeva, Shahnoza; Ayombil, Francis; Shepeliuk, Taisia; Grishchuk, Ekaterina L.; Ataullakhanov, Fazoil I.; Litvinov, Rustem I.; Weisel, John W.

doi:10.1016/j.jtha.2023.05.022

Cited by 7 publications

(2 citation statements)

References 59 publications

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“…First, it plays a key role in maintaining the shape of red blood cells (Vaisey et al, 2022). By sensing extracellular mechanical forces, Piezo1 can regulate the morphology of the cell membrane and ensure the adaptability and functionality of red blood cells (Vaisey et al, 2022;Evtugina et al, 2023;Hatem et al, 2023). Secondly, Piezo1 is involved in the regulation of immune responses (Atcha et al, 2021a;Lai et al, 2022).…”

Section: Structure and Characteristics Of Piezo1mentioning

confidence: 99%

Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases

Xu,

Huang,

Cheng

et al. 2023

Front. Mol. Biosci.

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Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat to global health. Early treatment of fibrosis has been reported to be the turning point, therefore, exploring potential correlates in the pathogenesis of fibrosis and how to reverse fibrosis has become a pressing issue. As a mechanism-sensitive cationic calcium channel, Piezo1 turns on in response to changes in the lipid bilayer of the plasma membrane. Piezo1 exerts multiple biological roles, including inhibition of inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, and immune cell mechanotransduction, interestingly enough. These processes are closely associated with the development of fibrotic diseases. Recent studies have shown that deletion or knockdown of Piezo1 attenuates the onset of fibrosis. Therefore, in this paper we comprehensively describe the biology of this gene, focusing on its potential relevance in pulmonary fibrosis, renal fibrosis, pancreatic fibrosis, and cardiac fibrosis diseases, except for the role of drugs (agonists), increased intracellular calcium and mechanical stress using this gene in alleviating fibrosis.

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Section: Structure and Characteristics Of Piezo1mentioning

confidence: 99%

Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases

Xu,

Huang,

Cheng

et al. 2023

Front. Mol. Biosci.

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“…Antagonizing Piezo1 causes a decrease in clot contraction relative to the control group. Therefore, it can be inferred that the activation of Piezo1 by compressed and deformed red blood cells amplifies platelet contractility, forming a positive feedback mechanism during the contraction of blood clots ( Evtugina et al, 2023 ). Piezo1 can not only affect calcium homeostasis but also directly intervene in red blood cell degradation by regulating iron metabolism.…”

Section: Basic Information On Piezo1mentioning

confidence: 99%

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

Zhang,

Zou,

Dou

et al. 2024

Front. Physiol.

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Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein. Piezo1 has various effects and plays an important and irreplaceable role in the maintenance of human life activities and homeostasis of the internal environment. In addition, recent studies have shown that Piezo1 plays a vital role in tumorigenesis, progression, malignancy and clinical prognosis. Piezo1 is involved in regulating the malignant behaviors of a variety of tumors, including cellular metabolic reprogramming, unlimited proliferation, inhibition of apoptosis, maintenance of stemness, angiogenesis, invasion and metastasis. Moreover, Piezo1 regulates tumor progression by affecting the recruitment, activation, and differentiation of multiple immune cells. Therefore, Piezo1 has excellent potential as an anti-tumor target. The article reviews the diverse physiological functions of Piezo1 in the human body and its major cellular pathways during disease development, and describes in detail the specific mechanisms by which Piezo1 affects the malignant behavior of tumors and its recent progress as a new target for tumor therapy, providing new perspectives for exploring more potential effects on physiological functions and its application in tumor therapy.

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Composition of thrombi in zebrafish: similarities and distinctions with mammals

Griffin,

Dahlgren,

Nagaswami

et al. 2024

Journal of Thrombosis and Haemostasis

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Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots

Cited by 7 publications

References 59 publications

Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases

Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

Composition of thrombi in zebrafish: similarities and distinctions with mammals

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