Activation of PmRelish from Penaeus monodon by yellow head virus

Visetnan, Suwattana; Supungul, Premruethai; Hirono, Ikuo; Tassanakajon, Anchalee; Rimphanitchayakit, Vichien

doi:10.1016/j.fsi.2014.11.015

Cited by 36 publications

(15 citation statements)

References 36 publications

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“…All but penaeidin5 were under the Toll pathway. The expression results of penaeidin3 and 5 agreed well with our previous results and suggested that the expression of penaeidin3 was partly under the regulation of Toll and Imd pathways whereas that of penaeidin5 was under the control of Imd pathway [25,26]. We also found in those previous studies that the expression of ALFPm3 was not under the Imd regulation but, in this study, under the Toll pathway.…”

Section: Discussionsupporting

confidence: 92%

Characterization of PmSpӓtzle 1 from the black tiger shrimp Peneaus monodon

Boonrawd

Mani

Ponprateep

et al. 2017

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 92%

Characterization of PmSpӓtzle 1 from the black tiger shrimp Peneaus monodon

Boonrawd

Mani

Ponprateep

et al. 2017

Fish & Shellfish Immunology

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“…Furthermore, TmRelish is a longer form of Relish, as the shorter form contains only the RHD and IPT domains. The short and long forms of Relish are more common in crustaceans such as shrimps; the giant tiger prawn, Penaeus monodon, and the giant freshwater prawn, Macrobrachium rosenbergii, encode long forms of Relish 36,46 , whereas shorter isoforms have been identified in the Chinese shrimp, Fenneropenaeus chinensis, and the white leg shrimp, Litopenaeus vannamei 47 . Among insects, both the long and short forms of Relish have been identified in Anopheles gambiae and are believed to be formed by the alternative splicing of Relish2 48 .…”

Section: Discussionmentioning

confidence: 99%

TmRelish is required for regulating the antimicrobial responses to Escherichia coli and Staphylococcus aureus in Tenebrio molitor

Keshavarz

Patnaik

et al. 2020

Sci Rep

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Relish, a transcription factor, is a critical downstream component of the immune deficiency (Imd) pathway and regulates host defense against bacterial infection by mediating antimicrobial peptide (AMP) synthesis. Understanding the immunological function of the mealworm beetle, Tenebrio molitor Relish (TmRelish) will be instructive in understanding insect immunity. In the present study, full-length oRf of TmRelish was retrieved from T. molitor-expressed sequence tags and RNA-seq database. The predicted TmRelish amino acid sequence contained an N-terminal Rel-homology domain; an Ig-like, plexin, and transcription factor domain; ankyrin repeat motifs; a nuclear localization signal; and a C-terminal death domain and shared the highly conserved structure of the Relish proteins of other insect species. TmRelish mRNA was detected in all developmental stages of the insect; however, the highest levels were detected in the larval gut tissue and adult hemocytes. TmRelish mRNA level was upregulated in the fat body, hemocyte, and gut tissue 9 h after infection of T. molitor larvae by the gram-negative bacteria, Escherichia coli. Furthermore, TmRelish knockdown led to significantly higher mortality of the E. coli-infected larvae, and significantly lower mortality of larvae infected with Staphylococcus aureus or Candida albicans. To elucidate the possible cause of mortality, we measured AMP transcription in the fat body, hemocytes, gut, and Malpighian tubules (MTs) of T. molitor larvae. TmRelish knockdown suppressed the expression of nine AMP genes in the larval fat body and gut tissue during E. coli infection, suggesting that TmRelish positively regulates AMP expression in both immunerelated tissues, in response to E. coli challenge. Furthermore, negative regulation of some AMPs by TmRelish in the MTs, gut and hemocytes in response to C. albicans infection suggests a crosstalk between the Toll and Imd pathways.

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“…Although these experiments are primarily performed in vivo and do not provide information about the specific functions of different hemocyte types, these studies have clarified the roles of some proteins in hemocyte functions, such as phagocytosis (Han et al, 2010;Wang et al, 2014), coagulation (Fagutao et al, 2012;Maningas et al, 2008) and viral defense Visetnan et al, 2015)). These techniques have also been successfully used to confirm the important role of the proPO-activating system as an early defense system Charoensapsri et al, 2009;Fagutao et al, 2009;Jang et al, 2011).…”

Section: Functionmentioning

confidence: 99%

Crustacean hematopoiesis

Söderhäll

2016

Developmental & Comparative Immunology

168

138

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Crustacean hemocytes are important mediators of immune reactions, and the regulation of hemocyte homeostasis is of utmost importance for the health of these animals. This review discusses the current knowledge on the lineages, synthesis and differentiation of hemocytes in crustaceans. Hematopoietic tissues, their origins, and the regulation of hematopoiesis during molting, seasonal variation and infection are discussed. Furthermore, studies concerning the molecular regulation of hemocyte formation in crustaceans are also described, and the different lineages and their molecular markers are discussed and compared with several insect species. Signaling pathways and the regulation of hematopoiesis by transcription factors are typically conserved among these arthropods, whereas cytokines and growth factors are more variable and species specific. However, considering the great diversity among the crustaceans, one should be cautious in drawing general conclusions from studies of only a few species.2

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Activation of PmRelish from Penaeus monodon by yellow head virus

Cited by 36 publications

References 36 publications

Characterization of PmSpӓtzle 1 from the black tiger shrimp Peneaus monodon

Characterization of PmSpӓtzle 1 from the black tiger shrimp Peneaus monodon

TmRelish is required for regulating the antimicrobial responses to Escherichia coli and Staphylococcus aureus in Tenebrio molitor

Crustacean hematopoiesis

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