1997
DOI: 10.1002/(sici)1097-4652(199702)170:2<153::aid-jcp7>3.0.co;2-n
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Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis

Abstract: We studied the roles of protein kinase A (PKA) activation and cyclic AMP response element binding protein (CREB) phosphorylation in chondrogenesis using serum-free chicken limb bud micromass cultures as a model system. We showed the following points: 1) in micromass cultures, activation of PKA enhances chondrogenesis and increases the phosphorylation of CREB; 2) BMP-2, a chondrogenic stimulator, increases PKA activity and the level of phosphorylated CREB (P-CREB); 3) H8, a PKA inhibitor, inhibits chondrogenesi… Show more

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Cited by 78 publications
(59 citation statements)
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“…Indeed, there is a complex synergism between Sox9 function and the cAMP-PKA-CREB pathway in both mature and differentiating chondrocytes [14]. Earlier results of our laboratory and others also confirmed the involvement of PKA in the regulation of in vitro chondrogenesis [18,19].…”
Section: Introductionsupporting
confidence: 66%
“…Indeed, there is a complex synergism between Sox9 function and the cAMP-PKA-CREB pathway in both mature and differentiating chondrocytes [14]. Earlier results of our laboratory and others also confirmed the involvement of PKA in the regulation of in vitro chondrogenesis [18,19].…”
Section: Introductionsupporting
confidence: 66%
“…Thus, we conclude that PKA plays a prominent role in eNOS phosphorylation in response to BMPs. It is interesting to note that there is little evidence of BMP/BMPRII-mediated PKA activation in the literature, although BMP2 has been shown to activate PKA in chondrocytes (19).…”
Section: Discussionmentioning
confidence: 99%
“…4), epidermal growth factor, and other epithelial growth factor receptor ligands (5). Importantly, BMP regulation of epithelial branching morphogenesis in model systems and lower organisms has been shown to depend on cAMP-dependent protein kinases (3,6,7), although the individual roles played by different genes encoding these kinases in vertebrate epithelial organ development has yet to be systematically investigated.…”
mentioning
confidence: 99%