1972
DOI: 10.1016/0049-3848(72)90036-9
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Activation of prothrombin with Taipan snake venom

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Cited by 30 publications
(9 citation statements)
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“…This reinforces the fundamental importance of including both co-factors in order to replicate physiological conditions. While some venom studies have done this (Bos et al, 2016;Chester and Crawford, 1982;Lister et al, 2017;Oulion et al, 2018;Pirkle et al, 1972;Rogalski et al, 2017), the inclusion of which is necessary to replicate physiological conditions, while others have neglected to include phospholipid (Isbister et al, 2010;Nielsen et al, 2018;O'Leary and Isbister, 2010;Still et al, 2017;Vargas et al, 2011), or both cofactors (Ainsworth et al, 2018;Resiere et al, 2018;Williams et al, 1994) thereby skewing the results and hampering the interpretation as to the effects upon coagulation and therefore limiting the clinical and evolutionary relevance of the results.…”
Section: Discussionmentioning
confidence: 99%
“…This reinforces the fundamental importance of including both co-factors in order to replicate physiological conditions. While some venom studies have done this (Bos et al, 2016;Chester and Crawford, 1982;Lister et al, 2017;Oulion et al, 2018;Pirkle et al, 1972;Rogalski et al, 2017), the inclusion of which is necessary to replicate physiological conditions, while others have neglected to include phospholipid (Isbister et al, 2010;Nielsen et al, 2018;O'Leary and Isbister, 2010;Still et al, 2017;Vargas et al, 2011), or both cofactors (Ainsworth et al, 2018;Resiere et al, 2018;Williams et al, 1994) thereby skewing the results and hampering the interpretation as to the effects upon coagulation and therefore limiting the clinical and evolutionary relevance of the results.…”
Section: Discussionmentioning
confidence: 99%
“…However, due to inherent difficulties in working with blood enzyme cascades, research into coagulotoxicity has lagged behind other intensively studied areas such as neurotoxicity. In addition, of the coagulotoxin studies that have been undertaken, only some [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ] have included in the experimental design the cofactors calcium and phospholipid, which are necessary to replicate physiological conditions in in vitro assays. Other studies have included only calcium [ 10 , 11 , 12 , 13 , 14 , 15 ], or neither cofactor [ 16 , 17 , 18 ], leading to deficiencies in replicating physiological conditions and interfering with accurate interpretation of the effects upon coagulation.…”
Section: Introductionmentioning
confidence: 99%
“…Routine coagulation studies and coagulation factor assays were done by conventional methods (14,15). Taipan venom times were performed as described by Pirkle et al (16), and Echis carinatus times were performed as described by Franza et Platelet-rich plasma was obtained by centrifugation of citrated venous blood at 180 g for 15 min at 22°C. The platelets were sedimented by further centrifugation at 22°C, 1,500 g, for 15 min.…”
Section: Introductionmentioning
confidence: 99%