Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1)

Umarova, B. A.; Dugina, T. N.; Шестакова, Е. В.; Gluza, E.; Strukova, S. M.

doi:10.1007/bf02439253

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…21 In another study thrombin did stimulate heparin and hexosaminidase release. 23 In a murine mast cell preparation thrombin stimulated IL-6 and matrix metalloproteinase 9 release and mast cell adherence to fibronectin. 24 Also, thrombin enhanced mast cell response to low-level stimulation of FceRI.…”

Section: Function Of Proteases On Cells Involved In Allergic Respiratmentioning

confidence: 99%

The role of protease activation of inflammation in allergic respiratory diseases

Reed

Kita

2004

Journal of Allergy and Clinical Immunology

341

302

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Section: Function Of Proteases On Cells Involved In Allergic Respiratmentioning

confidence: 99%

The role of protease activation of inflammation in allergic respiratory diseases

Reed

Kita

2004

Journal of Allergy and Clinical Immunology

341

302

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“…PARs are also expressed on cells circulating within blood, including platelets [84][85][86] and immune response cells [85,[87][88][89][90][91], expressed on glial, astrocytes and neuronal cells of the nervous system [92][93][94][95][96], as well as cells located within the corneas [97], pancreas [98], liver [99][100][101], kidney [102,103], synovium [104], skeletal muscle [105] and bone [106,107].…”

Section: Physiological and Pathophysiolo-gical Roles Of Parsmentioning

confidence: 99%

Agonists and Antagonists of Protease Activated Receptors (PARs)

Barry¹,

Le²,

Fairlie

2006

CMC

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Protease activated receptors (PARs) are a category of G-protein coupled receptors (GPCRs) implicated in the progression of a wide range of diseases, including thrombosis, inflammatory disorders, and proliferative diseases. Signal transduction via PARs proceeds via an unusual activation mechanism. Instead of being activated through direct interaction with an extracellular signal like most GPCRs, they are self-activated following cleavage of their extracellular N-terminus by serine proteases to generate a new receptor N-terminus that acts as an intramolecular ligand by folding back onto itself and triggering receptor activation. Short synthetic peptides corresponding to this newly exposed N-terminal tethered ligand can activate three of the four known PARs in the absence of proteases, and such PAR activating peptides (PAR-APs) have served as templates for agonist/antagonist development. In fact much of the evidence for involvement of PARs in diseases has relied upon use of PAR-APs, often of low potency and uncertain selectivity. This review summarizes current structures of PAR agonists and antagonists, the need for more selective and more potent PAR ligands that activate or antagonize this intriguing class of receptors, and outlines the background relevant to PAR activation, assay methods, and physiological properties anticipated for PAR ligands.

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“…Both PAR-1 and PAR-2 have been identified on the MC surface [80]. In previous studies it was shown that thrombin causes degranulation of rat and human BMMCs [90,93].…”

Section: Ige−independent MC Activationmentioning

confidence: 99%

Intracellular signaling pathways in IgE-dependent mast cell activation

Kopeć

Panaszek

Wandalsen

2006

Arch. Immunol. Ther. Exp.

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Mast cells (MCs) are both central effectors and signaling cells in allergic reactions. Their key role in the immunopathology of asthma and other allergic diseases has been well documented. Molecular events leading to MC activation have not been yet fully established, however. Recent studies emphasize the key role of the protein tyrosine kinases Lyn and Fyn in MC signal transduction. The finding that Lyn kinase negatively regulates MC degranulation and that Fyn kinase enhances this effector response is of great importance. This creates new possibilities for therapeutic intervention in asthma and other allergic diseases. This review summarizes current knowledge on MC intracellular signaling and discusses the most recent strategies for the treatment of allergic diseases based on MC signaling pathway inhibition.

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Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1)

Cited by 12 publications

References 12 publications

The role of protease activation of inflammation in allergic respiratory diseases

The role of protease activation of inflammation in allergic respiratory diseases

Agonists and Antagonists of Protease Activated Receptors (PARs)

Intracellular signaling pathways in IgE-dependent mast cell activation

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