Activation of the BMP2/SMAD4 signaling pathway for enhancing articular cartilage regeneration of mesenchymal stem cells utilizing chitosan/alginate nanoparticles on 3D extracellular matrix scaffold

Zohri, Maryam; Arefian, Ehsan; Azizi, Zahra; Akbari Javar, Hamid; Shadboorestan, Amir; Fatahi, Yousef; Chogan, Faraz; Taheri, Mojtaba; Karoobi, Sepideh; Aghaee-Bakhtiari, Seyed Hamid; Bonakdar, Shahin; Gazori, Taraneh; Mohammadi, Saeid; Saadatpour, Fatemeh; Ghahremani, Mohammad Hossein

doi:10.1016/j.ijbiomac.2024.133995

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.133995

|View full text |Cite

Activation of the BMP2/SMAD4 signaling pathway for enhancing articular cartilage regeneration of mesenchymal stem cells utilizing chitosan/alginate nanoparticles on 3D extracellular matrix scaffold

Maryam Zohri,

Ehsan Arefian,

Zahra Azizi

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review

Yu,

Su,

Peng

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review

Yu,

Su,

Peng

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Cerium Oxide Nanoparticles-Reinforced GelMA Hydrogel Loading Bone Marrow Stem Cells with Osteogenic and Inflammatory Regulatory Capacity for Bone Defect Repair

Wang,

He,

Bai

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Effective bone defect repair has been a tough clinical challenge due to the complexity of the bone defect microenvironment. Hydrogels loaded with bone marrow mesenchymal stem cells (BMSCs) have been widely applied for bone regeneration. However, the low survival of BMSCs at the site of transplantation and lack of sufficient osteogenic induction capacity greatly limit their applications. In order to solve this puzzle, we fabricated gelatin methacryloyl (GelMA) hydrogels containing BMSCs with cerium oxide (CeO 2 ) nanoparticles via photo-cross-linking to endow the composite hydrogel with osteogenic induction ability and immune induction ability. In vitro results demonstrated that the GelMA-CeO 2 -BMSC hydrogel presented with good biocompatibility and excellent osteogenic induction ability. In addition, the GelMA-CeO 2 -BMSC hydrogel could inhibit M1 polarization and promote M2 polarization, providing a good environment for the growth and osteogenic differentiation of BMSCs. Besides, the GelMA-CeO 2 -BMSC hydrogel was transplanted into critical-sized calvarial defects, and the results further confirmed its excellent bone regeneration capacity. In conclusion, the composite hydrogel provides a perspective for bone repair due to the remarkable potential for application in bone regeneration.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Activation of the BMP2/SMAD4 signaling pathway for enhancing articular cartilage regeneration of mesenchymal stem cells utilizing chitosan/alginate nanoparticles on 3D extracellular matrix scaffold

Cited by 2 publications

References 52 publications

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review

Cerium Oxide Nanoparticles-Reinforced GelMA Hydrogel Loading Bone Marrow Stem Cells with Osteogenic and Inflammatory Regulatory Capacity for Bone Defect Repair

Contact Info

Product

Resources

About