2020
DOI: 10.1111/andr.12928
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Activation of the cannabinoid receptor type 2 by the agonist JWH133 promotes the first wave of in vitro spermatogenesis

Abstract: Background Oncological procedures have irreversible side effects on germ cells for childhood cancer survival boys. In vitro culture of prepubertal testicular tissue has been proposed to restore fertility; however, recent data on animal models showed that meiotic and post‐meiotic progression was impaired. Objectives As potential key inducers of the mitosis‐meiosis switch, type 2 cannabinoid receptor (CB2) has been proposed to play a central role in the meiotic entry of male germ cells. Herein, the in vitro firs… Show more

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Cited by 2 publications
(2 citation statements)
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“…Furthermore, more recent studies succeeded in producing functional sperm from primitive spermatogonia in explanted neonatal mouse testis tissues [21]. Since then, several researchers have used this methodology to display functional approaches to the study of mouse spermatogenesis [22][23][24][25][26][27][28][29].…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, more recent studies succeeded in producing functional sperm from primitive spermatogonia in explanted neonatal mouse testis tissues [21]. Since then, several researchers have used this methodology to display functional approaches to the study of mouse spermatogenesis [22][23][24][25][26][27][28][29].…”
mentioning
confidence: 99%
“…Further studies succeeded in producing functional sperm from primitive spermatogonia in explanted neonatal mouse testis tissues [21]. Since then, several researchers have used this methodology to display functional approaches to the study of mouse spermatogenesis [22][23][24][25][26][27][28][29][30]. Latest advances using modified methodologies built upon the foundation of original protocols, have proposed that culturing isolated spermatogonia tubules, as opposed to tissue masses, offer distinct advantages in precisely evaluating the diverse environmental factors influencing the progression of spermatogenesis [31].…”
mentioning
confidence: 99%