Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice

Qian, Haitao; Gao, Fei; Wu, Xuyang; Lin, Daoyi; Huang, Yongxin; Chen, Andi; Deng, Jianhui; Gong, Cansheng; Chen, Xiaohui; Zheng, Xiaochun

doi:10.1007/s00011-023-01804-1

Cited by 8 publications

(2 citation statements)

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“…This route could play an important part in SARS-CoV-2’s immune evasion mechanisms, making it a potential therapeutic target [ 43 ]. The interaction between CD200 and its receptor CD200R is known to suppress immune responses by inhibiting the PI3K/Akt signaling pathway [ 44 ], which SARS-CoV-2 may also use to weaken host immune defenses and facilitate viral persistence in the respiratory tract [ 44 ]. SARS-CoV-2 infects via the respiratory system and causes an inflammatory response by affecting a variety of cell types, including type II alveolar epithelial cells [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…The interaction between CD200 and its receptor CD200R is known to suppress immune responses by inhibiting the PI3K/Akt signaling pathway [44], which SARS-CoV-2 may also use to weaken host immune defenses and facilitate viral persistence in the respiratory tract [44]. SARS-CoV-2 infects via the respiratory system and causes an inflammatory response by affecting a variety of cell types, including type II alveolar epithelial cells [44]. The SARS-CoV-2 Spike (S) protein has been linked to the pathogenesis of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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In Silico Exploration of CD200 as a Therapeutic Target for COVID-19

Perovic,

Glisic,

Veljkovic

et al. 2024

Microorganisms

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SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemic. The presented study, performed by using the informational spectrum method (ISM), representing an electronic biology-based tool for analysis of protein–protein interactions, identified the highly conserved region of spike protein (SP) from SARS-CoV-2 virus, which is essential for recognition and targeting between the virus and its protein interactors on the target cells. This domain is suggested as a promising target for the drug therapy and vaccines, which could be effective against all currently circulating variants of SARS-CoV-2 viruses. The analysis of the virus/host interaction, performed by the ISM, also revealed OX-2 membrane glycoprotein (CD200) as a possible interactor of SP, which could serve as a novel therapeutic target for COVID-19 disease.

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Section: Discussionmentioning

confidence: 99%