Activation of the Chemokine Receptor 3 Pathway Leads to a Better Response to Immune Checkpoint Inhibitors in Patients with Metastatic Urothelial Carcinoma
Abstract:Immune checkpoint inhibitors (ICIs) have made important breakthrough in anti-tumor therapy, however, no single biomarker can accurately predict their efficacy. Studies have found that tumor microenvironment is a key factor for determining the response to ICI therapy. Cytokine receptor 3 (C-X-C Motif Chemokine Receptor 3, CXCR3) pathway has been reported to play an important role in the migration, activation, and response of immune cells. We analyzed survival data, genomics, and clinical data from patients with… Show more
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