Activation of the CXCL16/CXCR6 Pathway by Inflammation Contributes to Atherosclerosis in Patients with End-stage Renal Disease

Hu, Ze Bo; Chen, Yan; Gong, Yu Xiang; Gao, Min; Zhang, Yang; Wang, Gui Hua; Tang, Ri; Liu, Hong; Liu, Bi Cheng; Ling, Kun

doi:10.7150/ijms.16724

Cited by 23 publications

(17 citation statements)

References 27 publications

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“…Small tissue samples of liver and testicle were obtained, fixed and processed by routine histological techniques. Tissue sections of 5–6 μm thickness were stained with hematoxylin–eosin (H&E) or preserved for cholesterol/filipin staining [23, 24, 25]. Images were acquired using a Nikon 80i microscope.…”

Section: Methodsmentioning

confidence: 99%

A chronic high-fat diet causes sperm head alterations in C57BL/6J mice

Funes

Lancellotti

Santillán

et al. 2019

Heliyon

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A chronic-positive energetic balance has been directly correlated with infertility in men, but the involved mechanisms remain unknown. Herein we investigated weather in a mouse model a chronic feeding with a diet supplemented with chicken fat affects sperm head morphology. To accomplish this, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat (high-fat diet, HFD). At the end of the feeding regimen, we measured: redox and inflammatory changes, cholesterol accumulation in testis and analyzed testicular morphological structure and ultra-structure and liver morphology. We found that the mice fed HFD resembled some features of the human metabolic syndrome, including systemic oxidative stress and inflammation, this group showed an increment in the following parameters; central adiposity (adiposity index: 1.07 AE 0.10 vs 2.26 AE 0.17), dyslipidemia (total cholesterol: 153.3 AE 2.6 vs 175.1 AE 8.08 mg/dL), insulin resistance (indirect Insulin resistance index, TG/HDL-c: 2.94 AE 0.33 vs 3.68 AE 0.15) and fatty liver. Increased cholesterol content measured by filipin was found in the testicles from HFD (fluorescence intensity increase to 50%), as well as an alteration of spermiogenesis. Most remarkably, a disorganized manchette-perinuclear ring complex and an altered morphology of the sperm head were observed in the spermatozoa of HFD-fed mice. These results add new information to our understanding about the mechanisms by which systemic oxidative stress and inflammation may influence sperm-head morphology and indirectly male fertility.

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Section: Methodsmentioning

confidence: 99%

A chronic high-fat diet causes sperm head alterations in C57BL/6J mice

Funes

Lancellotti

Santillán

et al. 2019

Heliyon

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“…With respect to the kidneys, ADAM10 is expressed in renal tubular cells, and its activity affects the expression of specific brush-border genes ( Cong et al, 2011 ). Furthermore, ADAM10 has effects some renal diseases such as lupus nephritis, arterionephrosclerosis, and DN ( Gutwein et al, 2009a ; Hu et al, 2016 ; Lattenist et al, 2016 ; Orme et al, 2016 ).…”

Section: Adam10 and Adam17mentioning

confidence: 99%

Renal ADAM10 and 17: Their Physiological and Medical Meanings

Kato

Hagiyama

Ito

2018

Front. Cell Dev. Biol.

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A disintegrin and metalloproteinases (ADAMs) are a Zn2+-dependent transmembrane and secreted metalloprotease superfamily, so-called “molecular scissors,” and they consist of an N-terminal signal sequence, a prodomain, zinc-binding metalloprotease domain, disintegrin domain, cysteine-rich domain, transmembrane domain and cytoplasmic tail. ADAMs perform proteolytic processing of the ectodomains of diverse transmembrane molecules into bioactive mediators. This review summarizes on their most well-known members, ADAM10 and 17, focusing on the kidneys. ADAM10 is expressed in renal tubular cells and affects the expression of specific brush border genes, and its activation is involved in some renal diseases. ADAM17 is weakly expressed in normal kidneys, but its expression is markedly induced in the tubules, capillaries, glomeruli, and mesangium, and it is involved in interstitial fibrosis and tubular atrophy. So far, the various substrates have been identified in the kidneys. Shedding fragments become released ligands, such as Notch and EGFR ligands, and act as the chemoattractant factors including CXCL16. Their ectodomain shedding is closely correlated with pathological factors, which include inflammation, interstitial fibrosis, and renal injury. Also, the substrates of both ADAMs contain the molecules that play important roles at the plasma membrane, such as meaprin, E-cadherin, Klotho, and CADM1. By being released into urine, the shedding products could be useful for biomarkers of renal diseases, but ADAM10 and 17 per se are also notable as biomarkers. Furthermore, ADAM10 and/or 17 inhibitions based on various strategies such as small molecules, antibodies, and their recombinant prodomains are valuable, because they potentially protect renal tissues and promote renal regeneration. Although temporal and spatial regulations of inhibitors are problems to be solved, their inhibitors could be useful for renal diseases.

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“…Furthermore, vascular calcification is influenced by chronic inflammation. TNF-α and monocyte chemotactic protein-1 (MCP-1) levels are elevated in the radial arteries of subjects with chronic inflammation (Hu et al 2016). Substantial increase in the expression of bone morphogenic proteins-2 (BMP-2) (Li et al 2008), osteocalcin (Millar et al 2017), and collagen-1 (Watson et al 1998) indicates inflammation-triggered osteogenic cell differentiation in vascular tissues, which explains the role of osteogenic cells in vascular calcification.…”

Section: Vascular Ageingmentioning

confidence: 99%

Sleep, brain vascular health and ageing

et al. 2020

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Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66 shc , PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing.

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Activation of the CXCL16/CXCR6 Pathway by Inflammation Contributes to Atherosclerosis in Patients with End-stage Renal Disease

Cited by 23 publications

References 27 publications

A chronic high-fat diet causes sperm head alterations in C57BL/6J mice

A chronic high-fat diet causes sperm head alterations in C57BL/6J mice

Renal ADAM10 and 17: Their Physiological and Medical Meanings

Sleep, brain vascular health and ageing

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