Activation of the Estrogen Receptor Contributes to the Progression of Pulmonary Lymphangioleiomyomatosis via Matrix Metalloproteinase-Induced Cell Invasiveness

Glassberg, Marilyn K.; Elliot, Sharon J.; Fritz, Jason R.; Catanuto, Paola; Potier, M.; Donahue, Roger P.; Stetler-Stevenson, William G.; Karl, Michael

doi:10.1210/jc.2007-1283

Cited by 71 publications

(55 citation statements)

References 41 publications

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“…In such cases correlation with clinical features and CT scan is essential to increase the confidence level of diagnosis. In about half of cases the oestrogen and/or progesterone receptor can be detected by immunohistochemistry [26,27]. Further details concerning diagnostic and molecular pathology are provided in appendix 3 (available in the online supplementary material; www.erj.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

Johnson¹,

Cordier²,

Lazor³

et al. 2009

Eur Respir J

482

561

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Section: Diagnostic Criteriamentioning

confidence: 99%

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

Johnson¹,

Cordier²,

Lazor³

et al. 2009

Eur Respir J

482

561

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“…Immunohistochemical staining of LAM lesions demonstrates overexpression of MMPs and metalloproteinase inducers, as well as a paucity of the tissue inhibitor of metalloproteinases TIMP-1 (129)(130)(131). Although MMP-2 is the most abundantly expressed MMP in LAM tissue, serum levels of MMP-9, but not MMP-2, are elevated in patients (132)(133)(134).…”

Section: Cyst Formation In the Lungmentioning

confidence: 99%

Lymphangioleiomyomatosis — a wolf in sheep’s clothing

Henske

McCormack²

2012

J. Clin. Invest.

271

260

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Lymphangioleiomyomatosis (LAM) is a rare progressive lung disease of women. LAM is caused by mutations in the tuberous sclerosis genes, resulting in activation of the mTOR complex 1 signaling network. Over the past 11 years, there has been remarkable progress in the understanding of LAM and rapid translation of this knowledge to an effective therapy. LAM pathogenic mechanisms mirror those of many forms of human cancer, including mutation, metabolic reprogramming, inappropriate growth and survival, metastasis via blood and lymphatic circulation, infiltration/ invasion, sex steroid sensitivity, and local and remote tissue destruction. However, the smooth muscle cell that metastasizes, infiltrates, and destroys the lung in LAM arises from an unknown source and has an innocent histological appearance, with little evidence of proliferation. Thus, LAM is as an elegant, monogenic model of neoplasia, defying categorization as either benign or malignant.

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“…Pathological analysis and immunohistochemical staining combined with the CT examination and clinical manifestations were used to confirm the diagnosis of LAM. In approximately half of LAM cases, the ER and/or PR can be detected by immunohistochemistry (24). Therefore, tests for PR and ER may aid diagnosis, although staining for the ER and PR in the present case was negative.…”

Section: Discussionmentioning

confidence: 58%

Sporadic lymphangioleiomyomatosis with bloody sputum as an initial symptom: A case report and review of the literature

2015

Experimental and Therapeutic Medicine

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Abstract. Lymphangioleiomyomatosis (LAM) is an extremely rare lung disease affecting females of a childbearing age. The condition occurs sporadically or in association with tuberous sclerosis complex. The diagnosis of LAM is often delayed since the clinical symptoms and signs are non-specific. The present study reports the a case of a patient with LAM, in which bloody sputum was presented as the initial symptom. The 43-year-old female had experienced a small amount of bloody sputum over the previous five years. The patient was admitted to the Department of Respiratory Medicine at Taizhou People's Hospital (Taizhou, China) in 2012, reporting symptoms of a cough, shortness of breath and bloody sputum over the previous 10 days. A high-resolution computed tomography scan revealed multiple small circular thin-walled translucent areas in both lung fields. The initial diagnosis of the patient was LAM. A biopsy was performed using a video-assisted thoracoscopy. In conclusion, increased awareness and early diagnosis and treatment were determined to be key factors in ensuring a satisfactory prognosis.

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Activation of the Estrogen Receptor Contributes to the Progression of Pulmonary Lymphangioleiomyomatosis via Matrix Metalloproteinase-Induced Cell Invasiveness

Abstract: The invasion and destruction of lung parenchyma in LAM is, at least partially, an estrogen-MMP-driven process, which has major implications for therapeutic interventions.

Cited by 71 publications

References 41 publications

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

Lymphangioleiomyomatosis — a wolf in sheep’s clothing

Sporadic lymphangioleiomyomatosis with bloody sputum as an initial symptom: A case report and review of the literature

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