Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.)

Christensen, Kathrine Bisgaard; Jørgensen, Monica; Kotowska, Dorota; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Christensen, Lars Porskjær

doi:10.1016/j.jep.2010.07.054

Cited by 71 publications

(47 citation statements)

References 40 publications

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“…It has been attributed that dicarboxylic acids increases mitochondrial calcium levels, forming pores in the mitochondrial membrane and releasing cytochrome c into the cytosol, activating caspases (Rubic et al 2008). The 12-methoxycarnosinic acid which was found in the hydroalcoholic extract (ExtHS), previously was reported to interact with the nuclear peroxisome proliferator-activated receptor (PPARs) in mouse embryonic fibroblasts, and plays an important role in anti-diabetic responses, once they regulate glucose homeostasis, lipid metabolism and infl ammation (Christensen et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, many reports are using S. officinalis (L.) to analyze its pharmacological activity and studies have shown its potential as anti-inflammatory (Rodrigues et al 2012), antimicrobial (Garcia et al 2012), hypoglycemiant (Shafiee-Nick et al 2012), anti-diabetic (Christensen et al 2010), antioxidant (Generalic et al 2012), to prevent neurodegenerative disease (Takano et al 2011) and antitumor activity (Al-Barazanjy et al 2013, Akaberi et al 2015.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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Salvia offi cinalis (Lamiaceae) has been used in south of Brazil as a diary homemade, in food condiment and tea-beverage used for the treatment of several disorders. The objective of this study was to characterize chemical compounds in the hydroalcoholic (ExtHS) and aqueous (ExtAS) extract from Salvia offi cinalis (L.) by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-QTOF MS/MS), evaluate in vitro ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ), catalase (CAT-like) and superoxide dismutase (SOD-like) activity, moreover cytotoxic by MTT assay, alterations on cell morphology by giemsa and apoptotic-induced mechanism for annexin V/propidium iodide. Chemical identifi cation sage extracts revealed the presence of acids and phenolic compounds. In vitro antioxidant analysis for both extracts indicated promising activities. The cytotoxic assays using tumor (Hep-2, HeLa, A-549, HT-29 and A-375) and in non-tumor (HEK-293 and MRC-5), showed selectivity for tumor cell lines. Immunocytochemistry presenting a majority of tumor cells at late stages of the apoptotic process and necrosis. Given the results presented here, Brazilian Salvia offi cinalis (L.) used as condiment and tea, may protect the body against some disease, in particularly those where oxidative stress is involved, like neurodegenerative disorders, infl ammation and cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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“…Salvialeriafone which contains a spiro-dihydrofuran moiety attached to ring C of the norditerpenoid unit is the first example of norditerpene-diterpene conjugated abietanoid dimer. The probable origin of the spiro-dihydrofuran group is proposed to be through a nucleophilic addition/substitution between the 1,6,12-trihydroxy derivative of sibiriquinone B [81] and the 6-deoxo analogue of 14-hydroxytaxodion [82]. This compound exhibited antiproliferative activity against HeLa cells with an IC 50 value of 10.91 µM.…”

Section: Family Lamiaceaementioning

confidence: 99%

Untitled

2016

Planta Med

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“…(4) such carnosol and carnosic acid [167], major metabolites in sage and rosemary, and 12-O-methyl carnosic acid Fig. (4) [168] were disclosed as active components.…”

Section: One Of the Main Group Of Ppars Agonists Found In Plants Are mentioning

confidence: 99%

Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications

D’Auria¹,

Sepe²,

Zampella

2012

CTMC

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Nuclear receptors are key regulators of various processes including reproduction, development, and metabolism of xeno- and endobiotics. Research in the last two decades has focused to the development of novel drugs specifically targeting nuclear receptors for the treatment of a variety of diseases, such as cancer, diabetes, dyslipidemia, fatty liver disease, drug hepatotoxicity and cholestasis. The search for novel NRs agonists and antagonists with enhanced selectivity prompted the exploration of the extraordinary chemical diversity associated to natural products. In recent years a number of natural products were disclosed as ligands of NRs and proved to have remarkable affinity and in some cases peculiar mode of action. In this review the natural ligands of the subfamily NR1, NR2, and NR3 will be described with an emphasis to their mechanisms of action and pharmacological profiles.

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Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.)

Cited by 71 publications

References 40 publications

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Untitled

Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications

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