Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine

Tannich, Fatma; Tlili, Asma; Pintard, Coralie; Chniguir, Amina; Eto, Bruno; Dang, Pham My-Chan; Souilem, Ouajdi; El-Benna, Jamel

doi:10.1007/s10787-019-00655-9

Cited by 14 publications

(5 citation statements)

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“…These problems are likely to become hot spots and directions for future studies. Fatma’s team found that ketamine has beneficial effects on pilocarpine-induced temporal lobe epilepsy in mice and that administration within minutes of seizures avoids nerve damage caused by pilocarpine ( Tannich et al, 2020 ). However, the specific mechanism of epilepsy is unclear, and there is a lack of clinical studies on ketamine in epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

Xia

Luo

et al. 2022

Front. Integr. Neurosci.

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Mammalian target of rapamycin (mTOR) is an important molecule that regulates cell metabolism, growth, and proliferation in the nervous system. This study aimed to present the current study hot spots and predict the future development trend of the mTOR pathway in neurologic diseases using bibliometrics. We referred to the publications in the Web of Science Core Collection database. VOSviewer and CiteSpace programs were used to evaluate countries/regions, institutions, authors, journals, keywords, and citations showing the current study focus and predicting the future trend of mTOR in neuroscience. The search date ended on 19 June 2022, and there were 3,029 articles on mTOR in neuroscience from 2002 to 2021. Visual analysis showed that although the number of publications declined slightly in some years, the number of publications related to mTOR generally showed an upward trend, reaching its peak in 2021. It had the largest number of publications in the United States. Keywords and literature analysis showed that protein synthesis regulation, ischemia, mitochondrial dysfunction, oxidative stress, and neuroinflammation may be hot spots and future directions of the nervous system in mTOR studies. Recently, the most studied neurological diseases are Alzheimer’s disease (AD), tuberous sclerosis complex (TSC), and depression, which are still worthy of further studies by researchers in the future. This can provide a useful reference for future researchers to study mTOR further in the field of neuroscience.

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Section: Discussionmentioning

confidence: 99%

Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

Xia

Luo

et al. 2022

Front. Integr. Neurosci.

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“… 5 , 9 Consistently, elevated expression of NOX2 was revealed in brain tissues from mice model of epileptic ictus or middle cerebral artery occlusion (MCAO). 10 , 11 Also, NOX2 expression by astrocytes was significantly higher in TBI patients than in controls. 12 Overall, it is speculated that NOX2 may represent a potential biomarker of acute brain injury.…”

Section: Introductionmentioning

confidence: 91%

Elevated Serum NOX2 Levels Contribute to Delayed Cerebral Ischemia and a Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

Wang¹,

Ji²,

Wang³

et al. 2023

NDT

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Background NADPH oxidase 2 (NOX2) is highly expressed in injured brain tissues. We determined serum NOX2 levels of aneurysmal subarachnoid hemorrhage (aSAH) patients and further investigated correlation of serum NOX2 levels with disease severity, delayed cerebral ischemia (DCI) plus prognosis after aSAH. Methods Serum NOX2 levels were measured in 123 aSAH patients and 123 healthy controls. World Federation of Neurological Surgeons scale (WFNS) score and modified Fisher (mFisher) score were utilized to assess disease severity. Modified Rankin scale (mRS) score was used to evaluate the clinical prognosis at 90 days after aSAH. Relations of serum NOX2 levels to DCI and 90-day poor prognosis (mRS score of 3–6) were analyzed using multivariate analysis. Receiver operating characteristic curve (ROC) was built to evaluate the prognostic predictive capability. Results Serum NOX2 levels in aSAH patients, compared with healthy controls, were significantly increased, and were independently correlated with WFNS score, mFisher score and post-stroke 90-day mRS score. Patients with poor prognosis or DCI had significantly higher serum NOX2 levels than other remainders, and serum NOX2 levels independently predicted 90-day poor prognosis and DCI. Serum NOX2 had high prognosis and DCI predictive abilities, and their areas under ROC curve were similar to those of WFNS score and mFisher score. Conclusion Serum NOX2 levels are significantly associated with hemorrhage severity, poor 90-day prognosis and DCI in aSAH patients. Hence, complement NOX2 may serve as a potential prognostic biomarker after aSAH.

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“…[137] MPO expression is low in the normal brain, whereas MPO levels are substantially upregulated in epileptic regions. [138] It can catalyze hydrogen peroxide (H 2 O 2 ) and Clto produce HClO and other oxides, which can further activate MMPs to destroy the BBB, and increase OS in the brain. Zhang et al [139] verified that MPO increases in the corresponding brain tissue and that blocking MPO activity could delay and reduce seizures.…”

Section: Myeloperoxidase-responsive Probesmentioning

confidence: 99%

Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes

Zhao

Sun

2022

Advanced Materials

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Epilepsy is a recurrent, episodic, and complex neurological syndrome characterized by an enduring predisposition to epileptic seizures and consequent neurological, cognitive, psychological, and social problems. [1] An epileptic seizure is a transient occurrence of symptoms (such as temporary confusion, staring spells, uncontrollable jerking, and loss of awareness) caused by abnormal neuronal electrical activities. [2] As a serious health problem, epilepsy affects ≈1% of the global population, [3] and nearly 5 million people worldwide are diagnosed with epilepsy every year. Although there are now more than 20 antiseizure medications (ASMs) in active clinical use, [4] ≈20-30% of epilepsy patients fail to achieve sustained seizure freedom after adequate trial of two appropriately chosen ASMs. [5] These drugresistant epilepsy (DRE) patients are at an increased risk of injury and death, [6] unbearable medication burden and adverse effects, increased psychiatric and neurocognitive comorbidities, [7] and socioeconomic disadvantage. Therefore, the management of DRE in the clinic is a major challenge.Resection of the epileptic foci (EF), defined as the minimum area of the brain tissue that must be resected or disconnected for the abolishment of seizures, [8] is the most efficient approach for the treatment of DRE patients. [9] First, epilepsy surgery increases the prospects of patients being seizure-free. [10] Approximately 52% of the patients have no disabling seizures for 5 years after surgery, and nearly half of the patients remain free from seizures for 10 years. [11] Second, surgical treatment reduces DRE patients' mortality by two to three times [12] and extends life expectancy by an average of 5 years in comparison to patients who have received drug therapy. [13] Third, epilepsy surgery reduces individual medical expenditures for families. [14] Overall, these results suggest that DRE is potentially curable with surgical intervention. Accurate identification of the EF is a prerequisite for achieving satisfactory postsurgical outcomes. [15] However, only a small percentage of patients is recommended for surgical treatment because of the difficulty in defining EF. First, an initial clinical assessment, including history of epilepsy, semiology information, drug history, and comorbidity, will be performed in the clinic to confirm whether the patients are suitable for surgery. Next, high-resolution structural magnetic resonance imaging (MRI) and long-term inpatient video electroencephalography (EEG) are conducted. [16] If MRI shows Excising epileptic foci (EF) is the most efficient approach for treating drugresistant epilepsy (DRE). However, owing to the vast heterogeneity of epilepsies, EF in one-third of patients cannot be accurately located, even after exhausting all current diagnostic strategies. Therefore, identifying biomarkers that truly represent the status of epilepsy and fabricating probes with high targeting specificity are prerequisites for identifying the "concealed" EF. However, no systematic summary of thi...

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Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine

Cited by 14 publications

References 72 publications

Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

Elevated Serum NOX2 Levels Contribute to Delayed Cerebral Ischemia and a Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes

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