1989
DOI: 10.1016/0014-4827(89)90268-1
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Activation of the phosphatidylinositol cycle in spreading cells

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Cited by 14 publications
(5 citation statements)
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“…For example, diffusible signals, such as cyclic nucleotides and divalent ions generated by cell-matrix interactions, may alter the polymerization of cytoskeletal proteins (Inber and Folkman, 1989a). Cell spreading on fibronectin activates phosphatidylinositol turnover in BHK cells (Breuer and Wagener, 1989) and changes in intracellular pH in fibroblasts (Schwartz et al, 1989) . Many of these changes, including those involved in mitosis, may involve changes in the substratum-induced tension within the cytoskeleton (Inber and Folkman, 1989b) .…”
Section: Resultsmentioning
confidence: 99%
“…For example, diffusible signals, such as cyclic nucleotides and divalent ions generated by cell-matrix interactions, may alter the polymerization of cytoskeletal proteins (Inber and Folkman, 1989a). Cell spreading on fibronectin activates phosphatidylinositol turnover in BHK cells (Breuer and Wagener, 1989) and changes in intracellular pH in fibroblasts (Schwartz et al, 1989) . Many of these changes, including those involved in mitosis, may involve changes in the substratum-induced tension within the cytoskeleton (Inber and Folkman, 1989b) .…”
Section: Resultsmentioning
confidence: 99%
“…For example, spreading of cells on fibronectin can induce intracellular alkalinization (Ingber and Folkman, 1989b). Lymphocytes whose CDlla/CD18 integrins are cross-linked by antibodies have responded with increases in intracellular Ca 2+ and accumulation of inositol triphosphate (Pardi et al, 1989), A preliminary report involving a single time point showed a higher ratio of inositol mono-, di-, and tetrakis-phosphate (but not inositol triphosphate) in baby hamster kidney cells that had spread on fibronectin-coated plastic compared with those remaining rounded on uncoated plastic (Breuer and Wagener, 1989). However, the mechanisms underlying these infrequently described responses are far from clear.…”
Section: Underlying Mechanismsmentioning
confidence: 99%
“…Known involving integrins include the activation of platelet degranulation (Shattil and Brugge, 1991;Jans, 1992;Raghow, 1994), the Na+/H+ antiporter (Schwartz et al, 1991a,b;Schwartz, 1993), changes in intracellular levels of Ca21 (Ng-Sikorski et al, 1991), changes in the levels of phosphoinositide and inositol phosphates (Breuer and Wagner, 1989;McNamee et al, 1993;Chong et al, 1994), tyrosine phosphorylation (Guan et al, 1991;Kornberg et al, 1991Kornberg et al, , 1992Burridge et al, 1992;Juliano and Haskill, 1993), activation of mitogenactivated protein kinases (Schlaepfer et al, 1994;Chen et al, 1994a), and the release of cytokines that ultimately cause T cell proliferation (Matsuyama et al, 1989;Nojima et al, 1990;Shimizu et al, 1990;Fine and Kruisbeek, 1991;van Seventer et al, 1991). Although much has been learned regarding the role of integrins in cell adhesion and signal transduction, the specific signal transduction pathways that lead to cell adhesion still remain elusive.…”
Section: Introductionmentioning
confidence: 98%