Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation

Sato, Takako; Kitagawa, Junichi; Ren, Ke; Tanaka, Hiroshi; Tanabe, Aya; Watanabe, Tatsuhisa; Mitsuhashi, Yutaka; Iwata, Koichi

doi:10.2334/josnusd.47.65

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…Furthermore, the number of nociceptive neurons that can be analyzed in single-neuron recording studies is limited in any one animal. It is probable that these fiber differences and technical limitation in single-neuron recording may be involved in the distribu- Generally, we observed a pattern of organization of pERK-LI cell expression following capsaicin stimulation of the face that was similar to that reported in previous c-Fos studies Zhou et al, 1999;Takemura et al, 2000;Watanabe et al, 2002;Nomura et al, 2002;Bereiter et al, 2005;Sato et al, 2005;Sugiyo et al, 2005Sugiyo et al, , 2006. However, the distribution of pERK-LI cells was more restricted from the Vi/Vc zone through the Vc/C2 zone compared with previous reports of c-Fospositive neurons Mineta et al, 1995).…”

Section: Dorsoventral and Rostrocaudal Organization Of Perk-li Cellssupporting

confidence: 75%

“…Another approach that has been used is c-Fos labeling to delineate the arrangement of nociceptive neurons in the trigeminal spinal nucleus and upper cervical cord as well as spinal dorsal horn. After noxious stimulation of a variety of orofacial sites, Fos protein like-immunoreactive cells (Fos-LI cells) occur in the trigeminal spinal nucleus interpolaris (Vi) and caudalis (Vc) transition zone (Vi/Vc zone) and the Vc/C2 transition zone Iwata et al, 1998a;Zhou et al, 1999;Takemura et al, 2000;Nomura et al, 2002;Watanabe et al, 2002;Kawabata et al, 2004;Bereiter et al, 2005;Sato et al, 2005;Sugiyo et al, 2005Sugiyo et al, , 2006Shimizu et al, 2006) in a somatotopic arrangement, and their numbers increase as noxious stimulus intensity increases Mineta et al, 1995). However, it has been reported that the c-Fos expression starts at about 30 minutes and peaks about 1 hour after noxious stimulation (Hunt et al, 1987;Tokunaga et al, 1995) in both superficial and deep laminae of the spinal dorsal horn (DH; Bullitt, 1991), so it is very likely that c-Fos expression is not directly correlated with an activation of Vc and upper cervical nociceptive neurons following acute orofacial noxious stimulation.…”

Section: Indexing Terms: Somatotopic Organization; Nociceptive Neuronmentioning

confidence: 99%

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Organization of pERK‐immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

Noma

Tsuboi

Kondo

et al. 2008

J of Comparative Neurology

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To define the somatotopic arrangement of neurons in the trigeminal spinal subnucleus caudalis and upper cervical cord activated by acute noxious stimulation of various orofacial sites, pERK expression was analyzed in these neurons. After capsaicin injection into the tongue, lower gum, upper and lower lips, or mental region, pERK-like immunoreactive (pERK-LI) cells were distributed mainly in the dorsal half of the trigeminal spinal nucleus interporalis (Vi) and caudalis (Vc) transition zone (Vi/Vc zone), middle Vc, and Vc and upper cervical cord transition zone (Vc/C2 zone). pERK-LI cells were distributed throughout the dorsal to ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following capsaicin injection into the anterior hard palate, upper gum, buccal mucosa, or vibrissal pad and in the ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following snout, ophthalmic, or ocular injection of capsaicin. The rostrocaudal distribution area of pERK-LI cells was more extensive from the Vi/Vc zone to the Vc/C2 zone after intraoral injection than that after facial injection, and the rostrocaudal distribution of pERK-LI cells from the Vi/Vc zone to the Vc/C2 zone had a somatotopic arrangement, with the snout being represented most rostrally and ophthalmic, ocular, or mental regions represented most caudally. These findings suggest that the pERK-LI cells expressed from the Vi/Vc zone to the Vc/C2 zone following injection of capsaicin in facial and intraoral structures may be differentially involved in pain perception in facial and intraoral sites.

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Section: Dorsoventral and Rostrocaudal Organization Of Perk-li Cellssupporting

confidence: 75%

Section: Indexing Terms: Somatotopic Organization; Nociceptive Neuronmentioning

confidence: 99%

Organization of pERK‐immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

Noma

Tsuboi

Kondo

et al. 2008

J of Comparative Neurology

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“…The mechanism of an effect of TMJ inflammation at the contralateral side of CFA injection is unknown. Many studies have revealed that TMJ CFA injection induces a strong bilateral expression of Fos-LI cells in the Vi/Vc transition zone (Sato et al, 2005; Zhou et al, 1999). It has been reported that some primary afferent fibers cross the mid-line and reach the contralateral side (Jacquin et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats

Yamazaki

Ren

Shimada

et al. 2008

Experimental Neurology

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To evaluate the involvement of paratrigeminal nucleus (Pa5) nociceptive neurons in temporomandibular joint (TMJ) inflammation-induced pain and its autonomic correlates, we conducted behavioral, single unit recording and Fos immunohistochemical studies in anesthetized rats. Nocifensive behaviors to mechanical, heat or cold stimulation of the lateral face over the TMJ region were significantly enhanced in the TMJ-inflamed rats for 10–14 days after injection of complete Freund’s adjuvant (CFA) into the TMJ and gradually decreased at the end of the 14-day observation period. Lowering of the nocifensive threshold in TMJ-inflamed rats lasted longer in vagus nerve-transected rats than vagus nerve-intact rats. A large number of Fos-like immunoreactive (LI) cells were observed in the Pa5, and half of them were retrogradely labeled with Fluorogold (FG) injected into the parabrachial nucleus. Background activity of Pa5 wide dynamic range and nociceptive specific neurons was significantly higher in the TMJ-inflamed rats when compared with controls. Responses to mechanical stimuli were significantly higher in NS neurons in the TMJ-inflamed rats. All thermal responsive Pa5 neurons were exclusively sensitive to cold and the response to cold was significantly higher in the TMJ-inflamed rats compared with control rats. Vagus nerve stimulation significantly decreased responses to mechanical and cold stimuli as well as the background activity in TMJ-treated rats but not in TMJ-untreated rats. The present findings suggest that populations of Pa5 neurons are nociceptive and involved in TMJ inflammation-induced pain as well as in autonomic processes related to TMJ pain.

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“…Topical application of glutamate and morphine to the Vc/C1 region either facilitated or inhibited evoked activity of ~30% of corneal units tested in the Vi/Vc (Meng et al ., 1998). Following injection of the retrograde tracer Fluorogold into the Vi/Vc transition zone, retrogradely labeled cells were observed in the Vc/C1,2 region (Sato et al ., 2005). After lesions of the bilateral Vc, there is a selective reduction of inflammation-induced Fos-expressing neurons in the ventral Vi/Vc, but not in dorsal or intermediate Vi/Vc, or nucleus tractus solitarius (Sugiyo et al ., 2005).…”

Section: Functional Input and Output Of The Vi/vc Transition Zonementioning

confidence: 99%

The Role Of Trigeminal Interpolaris-Caudalis Transition Zone In Persistent Orofacial Pain

Ren

Dubner

2011

International Review of Neurobiology

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Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation

Cited by 9 publications

References 16 publications

Organization of pERK‐immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

Organization of pERK‐immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats

The Role Of Trigeminal Interpolaris-Caudalis Transition Zone In Persistent Orofacial Pain

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