2014
DOI: 10.1182/blood-2014-03-560466
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Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosis

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Cited by 8 publications
(22 citation statements)
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“…MAPK in this study) that were present before the inhibitor therapy. Since NTs can be released by mast cells as well as bone marrow stromal cells, our data, together with our recent report demonstrating SM induction by BDNF-mediated activation of TRKB [ 19 ], suggest an important role of autocrine and/or paracrine activation of TRKs in the pathogenesis of mastocytosis. Moreover, we show a significantly prolonged survival of mice xenotransplanted with HMC-1 cells by targeting both TRK and KIT compared with targeting KIT alone.…”
Section: Discussionsupporting
confidence: 74%
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“…MAPK in this study) that were present before the inhibitor therapy. Since NTs can be released by mast cells as well as bone marrow stromal cells, our data, together with our recent report demonstrating SM induction by BDNF-mediated activation of TRKB [ 19 ], suggest an important role of autocrine and/or paracrine activation of TRKs in the pathogenesis of mastocytosis. Moreover, we show a significantly prolonged survival of mice xenotransplanted with HMC-1 cells by targeting both TRK and KIT compared with targeting KIT alone.…”
Section: Discussionsupporting
confidence: 74%
“…In the TRKA/NGF group, four animals developed acute leukemia within 6 months after transplantation ( Supplementary Figure 1 ), while three animals developed SM within 12 months after transplantation. Consistent with SM induced by TRKB activation [ 19 ], abnormal mast cells mainly showed features of mature hypergranular mast cells (Figure 1B–1D ) [ 20 ]. These cells expressed CD25 , tryptase , KIT , and TRKA (Figure 1 , Supplementary Figure 2 ).…”
Section: Resultssupporting
confidence: 55%
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