2021
DOI: 10.21203/rs.3.rs-696245/v1
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Activation of α7nAChR Preserves Intestinal Barrier Integrity and Ameliorates Cholestasis Liver Fibrosis in Mice by Enhancing the HO-1 / STAT3 Signaling to Inhibit NF-κB Activation

Abstract: Background: Activation of alpha-7 nicotinic acetylcholine receptor (α7nAChR) can inhibit the systemic inflammatory response and preserve intestinal barrier integrity. This study aimed at elucidating the molecular mechanisms by which α7nAChR activation could inhibit intestinal barrier injury and cholestatic liver fibrosis in mice induced by bile duct ligation (BDL).Methods: The intestine-specific HO-1 knockout VillinCreHmox1-/- and control Hmox1floxp/floxp C57BL/6 mice were subjected to BDL. The therapeutic eff… Show more

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