Activation Strategies for Alkyl Precursors in Achieving C(sp³)–C(sp³) Cross-Coupling via Metallaphotoredox Catalysis

Abstract

C(sp 3 )−C(sp 3 ) bond formation is gaining more prominence, especially with a growing emphasis on building threedimensional chemical space in bioactive molecules, fine chemicals, and agrichemicals. Metallaphotoredox catalysis has emerged as an effective strategy for designing processes using diverse C(sp 3 ) precursors well suited for 1e − radical chemistry. This review summarizes the latest advancement in metallaphotoredox catalysis, addressing the long-standing challenges in C(sp 3 )−C(sp 3 ) crosscoupling, with a focus on the classification of reactions based on the distinct modes of activation of C(sp 3 ) precursor upon entering the catalytic cycle.