Active and intelligent inhaler device development

Tobyn, Mike; Staniforth, John N.; Morton, David Alexander Vodden; Harmer, Quentin J.; Newton, Mike E

doi:10.1016/j.ijpharm.2003.09.049

Cited by 38 publications

(7 citation statements)

References 9 publications

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“…While most DPIs are breath-activated, relying on inhalation for aerosol generation, several power-assisted devices (pneumatic, impact force, and vibratory) [64,65] have been developed or are currently under development. It has been suggested that if shear force and turbulence could be standardised using a dispersion mechanism that is independent of the patient's breath, high delivery efficiency and reproducibility might be achieved.…”

Section: Dry-powder Inhalation Devicementioning

confidence: 99%

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

179

113

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Section: Dry-powder Inhalation Devicementioning

confidence: 99%

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

179

113

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“…DiŠerent particle engineering approaches have been employed by various researchers to tailor the need of desired aerosolisation properties (e.g., particle morphology, density and surface characteristics) in theˆnal product. This includes manipulation of percentage ofˆnes and surface rugosity, 2) addition of ternary agents, 3) design of elongated particle, 4) addition of force controlling agents 5) or addition of hygroscopic growth inhibitors. 6) Spray drying is a unique single step constructive method for microencapsulation of drug in polymeric carriers.…”

Section: Introductionmentioning

confidence: 99%

Formulation Optimization and Characterization of Spray Dried Microparticles for Inhalation Delivery of Doxycycline Hyclate

Mishra

2011

YAKUGAKU ZASSHI

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The local delivery of antibiotics in the treatment of infectious respiratory diseases is an attractive alternative to deliver high concentration of antimicrobials directly to the lungs and minimize systemic side eŠects. In this study, inhalable microparticles containing doxycycline hyclate, sodium carboxymethylcellulose, leucine and lactose were prepared by spray drying of aqueous ethanol formulations. Box-Behnken design was used to study the in‰uence of various independent variables such as polymer concentration, leucine concentration, ethanol concentration and inlet temperature of the spray dryer on microparticle characteristics. The microparticles were characterized in terms of particle morphology, drug excipient interaction, yield, entrapment e‹ciency, Carr's index, moisture content, thermal properties, X-ray powder diŠraction, aerosolization performance and in vitro drug release. The eŠect of independent variables on spray dryer outlet temperature was also studied. The overall shape of the particles was found to be spherical like doughnuts in the size range of 1.16 5.2 mm. The optimized formulation (sodium carboxymethylcellulose concentration 14％ w/v, leucine concentration 33％ w/v, ethanol concentration 36％ v/v, inlet temperature of 140°C) exhibited the following properties: yield 56.69％, moisture content 3.86％, encapsulation e‹ciency 61.74％, theoretical aerodynamic diameter 3.11 mm and Carr's index 23.5％ at an outlet temperature 77°C. The powders generated were of a suitable mass median aerodynamic diameter (4.89 mm) with 49.3％ˆne particle fraction and exhibited a sustained drug release proˆle in vitro.

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“…The one-step spray-drying process has proved to be an effective way to prepare dry particles for pulmonary inhalation [7][8][9][10][11]. Methods for increasing the dispersibility and subsequent pulmonary deposition of spray-dried particles range from development of the drying process, addition of supplementary carrier particles [12], and inhaler device modifications [3,[13][14][15]. Previously, our laboratory has reported that the dispersibility of spray-dried powders for pulmonary gene therapy can be improved through additional formulation components [16,17].…”

Section: Introductionmentioning

confidence: 99%