Active compounds of medicinal plants, mechanism for antioxidant and beneficial effects

Abstract

An increased interest in the antioxidant effects of medicinal plants has developed in recent years. Identifying antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research community. We performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in plants. The result of this review is presented as a description of free radicals, as well as cellular and physiological oxidative stress, is provided. The origin and source of antioxidant compounds, and the cellular and molecular mechanism by which they exert antioxidant effects, have been reported. The absorption, distribution and, elimination of antioxidants are mentioned. The beneficial effects of secondary metabolites of medicinal plants in various high incidence disease conditions were also reviewed. Finally, disease states that benefit from antioxidant compounds includes diabetes, cancer, cardiovascular diseases, and liver, brain and, intestinal diseases.

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

“…Therefore, medicinal plants have been recently exploited to screen new agents with androgen-like effects. 20,21 Based on histological characteristics of the prostate and testis of rats in experimental group and other groups, we found no significant pathological changes of the prostate and testis in experiment group, which indicates that testosterone propionate may be safe for short-term use.However, we should point out some limitations of the intervention with testosterone propionate. For instance, rats in the experimental group were more aggressive compared to control group, such as fighting, baiting, and they had more active sexual behavior.…”

A2AR Antagonism with DZD2269 Augments Antitumor Efficacy of Irradiation in Murine Model

“…A 2A R antagonism can protect immune cells from the immunosuppressive effect caused by pre-existing extracellular adenosine accumulation as well as IR-induced adenosine release in the TME. Further studies are necessary to screen novel compounds of A2AR antagonist with better antitumor effects and less side effects from natural products [43,44].…”

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

“…Long-term usage of exogenous androgen may inhibit male gonads, and common complications include testicular atrophy and prostatic hyperplasia, which severely limits its clinical application [20]. Therefore, medicinal plants have been exploited to screen new agents with androgen-like effects [21,22]. Based on histological characteristics of the prostate and testis of rats in experimental group and other groups, we found no significant pathological changes of the prostate and testis in experiment group, which indicates that testosterone propionate may be safe for short-term use.…”