Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system

Bowen, Michael T.; Dass, Shantala A. Hari; Booth, John D.; Suraev, Anastasia; Vyas, Ajai; McGregor, Iain S.

doi:10.1016/j.yhbeh.2014.08.004

Cited by 39 publications

(34 citation statements)

References 48 publications

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“…In a different ELS study in adult rats decreased AVP enhancer locus methylation in amygdala found associated with development of active coping mechanisms when presented with predatory stress challenge (141).…”

Section: Evidences From Animal Model Studiesmentioning

confidence: 94%

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Kumar¹,

Kumar²,

Pareek³

et al. 2017

Preprint

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Apart from their established role in embryonic development Nerve Growth Factors (NGFs) have diverse functions in the nervous system. Their role in integration of physiological functioning of the nervous system is now attracting attention. In the present analysis, we propose a new paradigm about a novel role of NGFs. We hypothesize that NGFs play imperative role in maintaining psychological integrity of an individual as a biological system. This function may be mediated through HPA-axis-operated homeostatic mechanisms; stress induced disruption of which may lead to psychiatric disorders.

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Section: Evidences From Animal Model Studiesmentioning

confidence: 94%

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Kumar¹,

Kumar²,

Pareek³

et al. 2017

Preprint

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show abstract

“…Such overexpression of AVP can result in HPA axis hyperactivity and altered coping mechanisms that resemble depression in humans. In adult animals, decreased AVP promoter methylation in the amygdala is associated with active coping mechanisms after exposure to stressful stimuli 211 , and AVP expression is associated with aggressive behaviour [212][213][214] . Collectively, animal studies on early-life environmental variation 74,204 indicate that the early environment epigenetically regulates diverse genomic loci that are important in the regulation of emotional and behavioural traits of relevance to depression and suicide.…”

Section: Box 1 | Biological Embedding Through Dna Methylationmentioning

confidence: 99%

The molecular bases of the suicidal brain

2014

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Suicide ranks among the leading causes of death around the world and takes a heavy emotional and public health toll on most societies. Both distal and proximal factors contribute to suicidal behaviour. Distal factors - such as familial and genetic predisposition, as well as early-life adversity - increase the lifetime risk of suicide. They alter responses to stress and other processes through epigenetic modification of genes and associated changes in gene expression, and through the regulation of emotional and behavioural traits. Proximal factors are associated with the precipitation of a suicidal event and include alterations in key neurotransmitter systems, inflammatory changes and glial dysfunction in the brain. This Review explores the key molecular changes that are associated with suicidality and discusses some promising avenues for future research.

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“…The mice also presented despair like behaviour and memory deficit which were supposedly mediated through AVP signalling and epigenetic adaptations at AVP enhancer locus (140). A persistent increase in AVP expression was found in hypothalamic paraventricular nuclei (PVN) associated with decreased DNA methylation at AVP enhancer locus in an another ELS study done in mice (141).…”

Section: Evidence From Animal Studiesmentioning

confidence: 88%

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

Kumar¹,

Kumar²,

Ma³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system

Cited by 39 publications

References 48 publications

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

The molecular bases of the suicidal brain

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

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