This study is a comparative analysis of online distance learning and traditional in-person education at King Saud University in Saudi Arabia, with a focus on understanding how different educational modalities affect student achievement. The justification for this study lies in the rapid shift towards online learning, especially highlighted by the educational changes during the COVID-19 pandemic. By analyzing the final test scores of freshman students in five core courses over the 2020 (in-person) and 2021 (online) academic years, the research provides empirical insights into the efficacy of online versus traditional education. Initial observations suggested that students in online settings scored lower in most courses. However, after adjusting for variables like gender, class size, and admission scores using multiple linear regression, a more nuanced picture emerged. Three courses showed better performance in the 2021 online cohort, one favored the 2020 in-person group, and one was unaffected by the teaching format. The study emphasizes the crucial need for a nuanced, data-driven strategy in integrating online learning within higher education systems. It brings to light the fact that the success of educational methodologies is highly contingent on specific contextual factors. This finding advocates for educational administrators and policymakers to exercise careful and informed judgment when adopting online learning modalities. It encourages them to thoroughly evaluate how different subjects and instructional approaches might interact with online formats, considering the variable effects these might have on learning outcomes. This approach ensures that decisions about implementing online education are made with a comprehensive understanding of its diverse and context-specific impacts, aiming to optimize educational effectiveness and student success.