In the operation process of a power battery pack, the inconsistency among lithium-ion cells may seriously restrict the pack’s capacity, power capability and lifetime, which may bring hidden danger to the use of electric vehicles. Equalization management systems (EMSs) are crucial to alleviate such inter-cell inconsistency, whose performance such as accuracy and stability, mainly depends on the setting of equalization control strategies. This paper proposes an equalization strategy aimed at throughput maximization of series battery in the whole life cycle based on Model Prediction Control (MPC). In this paper, a Mean-plus-difference model (M+D) model is selected as the series battery model and the parameters are identified by Recursive Least Squares (RLS). Based on the model predictive control theory, the control model of series battery pack is established and the objective function of maximizing the throughput in the whole life cycle is derived. At the end of the paper, the simulation results show that the proposed equalization strategy can achieve greater life cycle throughput compared with the traditional SOC equalization strategy, which verifies the guiding significance of the equilibrium strategy proposed in this paper.