Unsteady pulsed holed suction as a new unsteady flow control technique is first proposed. Unsteady excitation models of four different waveforms (Waveforms 1, 2, 3, and 4) based on unsteady pulsed holed suction are investigated to analysis comparatively the control effects of flow separations in a certain highly loaded compressor. Some related unsteady aerodynamic parameters such as excitation frequency and excitation location are studies. The unsteady pulsed holed suctions of the four different modes (Waveforms 1, 2, 3, and 4) all effectively control flow separations. Their optimum frequencies are all an integer multiple of the natural frequency of vortex shedding. And their excitation locations gaining positive effect and optimal excitation locations are both same. The optimal excitation location is near the separation point of upper endwall in unexcited case. But, they show markedly different performances in reducing the total pressure losses. The unsteady pulsed holed suction of Waveform 3 shows greater advantage at different excitation frequencies and excitation locations. The optimum result is obtained by the unsteady pulsed holed suction of Waveform 3. The total pressure loss is reduced by 16.8%. Simultaneously, the unsteady pulsed holed suctions of the four different modes all can provide better effects than the steady constant holed suction in reducing the total pressure loss with the same suction-to-inlet time-averaged suction flow ratio ms. Especially at ms = 0.29%, for the steady constant holed suction, it is too small to effectively control flow separation, and consequently the total pressure loss are increased by 8.3%. However, for the unsteady pulsed holed suctions of Waveforms 2 and 3, the total pressure losses are reduced by 9.1% and 4.3%, respectively.