Active Human Herpesvirus 6 Infection in a Patient with Drug Rash with Eosinophilia and Systemic Symptoms

Abstract

increase the PPV to 0.59 if the result is positive, or yield an acceptable 1-NPV of 0.004 if the test is negative, and thus provides important information to the clinician attempting to make a dif-¢cult decision. Selective use in settings where the decision to biopsy may result in an adverse patient outcome may be a potential use for computerized digital dermoscopy. When assessing the clinical relevance of diagnostic technology, clinicians must consider a test's PPV and 1-NPV (not just its sensitivity and speci¢city) and the pre-test probabilities where its use may inform clinical decisions. Whereas Rubegni et al's tool appears to be a powerful diagnostic aid, whether the additional amount of clinical information the tool provides justi¢es the cost of technology requires us to consider the broad determinants of medical decision-making: physician behavior, disease prevalence, outcome, cost, and values.

Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome

“…In patients with life-threatening systemic disease such as fulminant hepatitis or hemophagocytosis, antiviral treatments including ganciclovir and intravenous immunoglobulins have been considered as alternative treatments, but their efficacy has yet to be demonstrated, and they may even be deleterious. 1 , 8 , 9 …”