Active immunization of rabbits against progesterone: Increase in hormone levels, and changes in metabolic clearance rates and in genital tract tissues

Bochskanl, R.; Thie, Michael; Kirchner, C.

doi:10.1016/0022-4731(89)90323-3

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…Авторы расценили этот эффект как результат связывания Es специфическими АТ и угнетения пролиферации эстрогензависимых опухолевых клеток. В то же время, многочисленные эксперименты на различных видах животных продемонстрировали, что иммунизация против стероидных гормонов приводит к образованию специфических АТ, значительному повышению концентрации соответствующих гормонов в крови и модулированию их биологических функций [20,50,58]. В некоторых экспериментах иммунизации против одного гормона сопровождалась повышением содержания в крови другого гормона.…”

Section: иммуномодуляция химического канцерогенеза специфическими ант...unclassified

Immune-hormonal imbalance in chemical cancerogenesis

Глушков¹

2022

Russian Journal of Immunology

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The present article deals with experimental and clinical aspects of immuno-hormonal interactions in chemical carcinogenesis i.e., formation of DNA-adducts with chemical carcinogens as a trigger of tumor initiation; synthesis of specific antibodies as markers of human exposure to environmental carcinogens; immunomodulation of chemical carcinogenesis by the specific antibodies in experimental studies; interactions of antibodies against environmental carcinogens with endogenous steroid hormones in human carcinogenesis; immunological interference and inversion of immuno-hormonal interactions by the action of antibodies against environmental carcinogens; immune stimulation of tumor progression in cancer patients. It is shown that antibodies specific to estradiol and progesterone participate in regulation of serum estradiol and progesterone levels in healthy women. Excessive production of antibodies against benzo[a]pyrene is associated with impaired physiological balance between the levels of antibodies to estradiol and progesterone, thus causing disturbed physiological balance between serum estradiol and progesterone. Immuno-hormonal imbalance promotes tumor initiation, its growth and progression. The new approaches to the personalized cancer immunoprediction and immune prevention are discussed. Coordinated synthesis of antibodies against benzo[a]pyrene and estradiol seems to reflect production of DNA-adducts with genotoxic metabolic effects of these compounds manifesting as synergistic carcinogenic effects upon the target cells. Hence, simultaneously increased levels of serum antibodies against benzo[a]pyrene and estradiol in healthy people may be considered an immunological marker of high oncological risk and an reason to use of new immunoprotective tools against polycyclic aromatic hydrocarbons and phytoestrogens. However, ability of these antibodies to raise the blood serum levels of environmental carcinogens and endogenous estradiol, as shown in vitro and in vivo, excludes the opportunity for active cancer immune prevention. Usage of anticarcinogen vaccines aimed for induction of protective secretory antibodies is likely to further increase high levels of procarcinogenic serum antibodies against benzo[a]pyrene and estradiol, followed by additional enhancement of immuno-hormonal imbalance and promotion of carcinogenesis. Development of probiotics transduced with genes encoding human antibodies against environmental carcinogens may present an alternative approach to cancer immune prevention. The antibodies produced by such probiotics would bind appropriate carcinogens and prevent their invasion into the organism, thus inhibiting emergence of DNA-adducts and suppressing synthesis of specific autoantibodies that may promote carcinogenesis. The aim is to substantiate the concept of immuno-hormonal imbalance for the carcinogen-induced hormone-dependent tumors.

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Section: иммуномодуляция химического канцерогенеза специфическими ант...unclassified

Immune-hormonal imbalance in chemical cancerogenesis

Глушков¹

2022

Russian Journal of Immunology

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“…С другой стороны, было показано, что иммунизация животных против Es и Pg приводила к появлению специфических антител и повышению концентрации гормонов в сыворотке крови [5][6][7][8]. После иммунизации мышей против Es наблюдали замедление возникновения и роста имплантированных Es-зависимых опухолей молочной железы, по предположению авторов, за счёт связывания Es антителами [9].…”

Section: Introductionunclassified

Effect of anti-antibodies to estradiol and progesterone on the concentration of hormones in the blood serum of healthy women and breast cancer patients

et al. 2020

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Ранее были выявлены взаимосвязи аутоантител, специфичных к эстрадиолу (Es) и прогестерону (Pg), с содержанием гормонов в сыворотке крови здоровых женщин и больных раком молочной железы. Цель исследования -выявить предполагаемые взаимосвязи антиидиотипических аутоантител к Es и Pg с содержанием гормонов в сыворотке крови здоровых женщин и больных раком молочной железы в постменопаузе. Материал и методы. Концентрации Es и Pg исследовали с помощью конкурентного метода иммуноферментного анализа в сыворотке крови 206 здоровых женщин и 480 больных раком молочной железы. В этих же образцах сыворотки крови исследовали уровни антител и антиидиотипических антител к Es и Pg с помощью конкурентного метода иммуноферментного анализа. Результаты. Высокие значения индивидуальных соотношений гормонов (Pg/Es>4,0) были ассоциированы с низким риском рака молочной железы (OR=0,3; р<0,0001), высокими значениями индивидуальных соотношений специфических аутоантител класса А (Iga-Pg1/Iga-Es1>1,0; р=0,004) и с высокими значениями соответствующих антиидиотипических антител класса G (IgG-Pg2/IgG-Es2>1,0; p<0,001) у здоровых женщин, но не у больных раком молочной железы. Заключение. Впервые обнаружены ассоциации антиидиотипических антител класса G к Es и Pg с гормональным статусом у здоровых женщин. Подобные иммуно-гормональные взаимосвязи у больных раком молочной железы отсутствовали. Это может служить основанием для дальнейших исследований механизмов иммунорегуляции канцерогенеза у человека.Ключевые слова: рак молочной железы, антиидиотипические антитела, эстрадиол, прогестерон.

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“…Активная иммунизация животных коньюгатами Pg-белок сопровождалась повышением в циркулирующей крови уровней Pg, Es и лютеинизирующего гормона [7,9,13,17] и нарушениями репродуктивных функций у самок [10,11,23].…”

Section: Introductionunclassified

Immunoregulation of Blood Serum Estradiol and Progesterone Levels in Postmenopausal Women

et al. 2019

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Specific antibodies against estradiol (Es) and progesterone (Pg) are known to modulate blood serum concentrations of these hormones and their biological effects after immunization of animals. It was suggested that specific IgA-Es and IgA-Pg could influence on Es and Pg levels in human blood serum. The purpose of this study was to identify the suggested correlations between serum Es and Pg and specific IgA-Es and IgA-Pg in postmenopausal healthy women (HW) and breast cancer patients (BCP). The serum levels of Es, Pg, IgA-Es and IgA-Pg were studied in 226 HW and 633 BCP by means of solid-phase immunoassay. The following results were obtained. The levels of Es in BCP (0.25 nmol/l) were higher than in HW (0.16; р < 0.0001). The levels of Pg were lower (0.79 vs 0.87; р < 0.0001), and individual Pg/Es ratios were lower (3.19 vs 6.64; р < 0.0001). Individual IgA-Pg/IgA-Es ratios correlated with decrease of Es (rs = -0.15; p = 0.029), with increase in Pg (rs = 0.38; р < 0.0001), and with increased Pg/Es ratio (rs = 0.29; р < 0.0001) in healthy women. Similar correlations were determined in BCP (correspondingly: rs = -0.14, р < 0.001; rs = 0.1, р = 0.009; rs = 0.15, р < 0.0001). The decrease of Es and increase of Pg and Pg/Es in BCP were less significant than in HW: the a quotients in regression у = ах+b (y = hormones levels and x = antibodies levels) in BCP were 3 to 4-fold lower than in HW. These peciliarities of interrelations between hormones and specific antibody levels were revealed only in ER+/PR+ BCP but not in ER+/PR- and ER-/PR- BCP. In conclusion, we have confirmed a suggestion about participation of specific antibodies in regulation of steroids levels in human blood serum. The immune regulation of hormonal status was weakened in BCP.

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Active immunization of rabbits against progesterone: Increase in hormone levels, and changes in metabolic clearance rates and in genital tract tissues

Cited by 8 publications

References 21 publications

Immune-hormonal imbalance in chemical cancerogenesis

Immune-hormonal imbalance in chemical cancerogenesis

Effect of anti-antibodies to estradiol and progesterone on the concentration of hormones in the blood serum of healthy women and breast cancer patients

Immunoregulation of Blood Serum Estradiol and Progesterone Levels in Postmenopausal Women

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