The slowdown of Moore’s Law necessitates an exploration of novel computing methodologies, new materials, and advantages in chip design. Thus, carbon-based materials have promise for more energy-efficient computing systems in the future. Moreover, sustainability emerges as a new concern for the semiconductor industry. The production and recycling processes associated with current chips present huge environmental challenges. Electronic waste is a major problem, and sustainable solutions in computing must be found. In this review, we examine an alternative chip design based on nanocellulose, which also features semiconductor properties and transistors. Our review highlights that nanocellulose (NC) is a versatile material and a high-potential composite, as it can be fabricated to gain suitable electronic and semiconducting properties. NC provides ideal support for ink-printed transistors and electronics, including green paper electronics. Here, we summarise various processing procedures for nanocellulose and describe the structure of exclusively nanocellulose-based transistors. Furthermore, we survey the recent scientific efforts in organic chip design and show how fully automated production of such a full NC chip could be achieved, including a Process Design Kit (PDK), expected variation models, and a standard cell library at the logic-gate level, where multiple transistors are connected to perform basic logic operations—for instance, the NOT-AND (NAND) gate. Taking all these attractive nanocellulose features into account, we envision how chips based on nanocellulose can be fabricated using Electronic Design Automation (EDA) tool chains.