Active Matrix Metalloproteinase-9 Is Associated with Clinical In-Stent Restenosis

Balta, Şevket; Demırkol, Sait; Çelik, Turgay; Ünlü, Murat; Arslan, Zekeriya; İyisoy, Atila

doi:10.1159/000350340

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…This hypothesis is supported by a meta-analysis of the risk of progression of IHD associated with an elevated MMP-9 level. 7 The meta-analysis discusses the results of 26 studies, which included 12,776 cases, where it was assumed that an increase in the level of MMP-9 is associated with progression of IHD. 8 It has also been shown that the activation of MMP-9 is associated with coronary artery restenosis following stent implantation.…”

Section: Introductionmentioning

confidence: 99%

“…8 It has also been shown that the activation of MMP-9 is associated with coronary artery restenosis following stent implantation. 2,7,9 Elevated levels of MMP-9 are associated with severe atherosclerotic processes in coronary arteries. 7,10 Thus, metalloproteinases MMP-9, PICP and TIMP-1 may participate in the pathogenesis of IHD and AH, although the cause-and-effect relationship remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

“…2,7,9 Elevated levels of MMP-9 are associated with severe atherosclerotic processes in coronary arteries. 7,10 Thus, metalloproteinases MMP-9, PICP and TIMP-1 may participate in the pathogenesis of IHD and AH, although the cause-and-effect relationship remains to be clarified. Currently, local and foreign literature is limited, hence the relevance of this study.…”

Section: Introductionmentioning

confidence: 99%

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The predictive role of cardiac fibrosis markers in progression of coronary heart disease associated with cardiac arrhythmias and arterial hypertension

Хлынова¹

2018

MOJBM

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The markers of cardiac fibrosis were studied in patients with coronary heart disease (CHD), arterial hypertension (AH) and atrial fibrillation (AF), as well as with CHD and AF without AH and in the group with isolated CHD. The change of levels of serum fibrosis markers were found in patients with coronary heart disease: C-terminal propeptide of procollagen I type (PICP), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1); the highest level was combined with hypertension and AF. The risk of CHD increases with increasing of concentrations of MMP-9 and PICP and decreasing of concentration of TIMP-1. Most predictive has MMP-9. The risk of progression of coronary artery disease increases when the level of MMP-9 more than 27.25 ng/ml, the level of PICP more than 99.6ng/ml, the level of TIMP-1 less than 465.3ng/ml. The risk of a critical stenosis of the coronary arteries increases with the level of MMP-9 more than 101.8ng/ ml, more values PICP 195.6ng/ml. The odds ratio for the MMP-9 was 3.41 (CI 1,38-8,47, P=0.007). The odds ratio for the PICP more than 195.6ng/ml was 4.66 (confidence interval 1,68-12,9; p=0.003).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The predictive role of cardiac fibrosis markers in progression of coronary heart disease associated with cardiac arrhythmias and arterial hypertension

Хлынова¹

2018

MOJBM

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“…Preprocedural serum inflammatory markers such as C-reactive protein may be associated with early complications and long-term outcome in patients undergoing a percutaneous coronary intervention [3]. Novel inflammatory markers have been considered as major risk factors predisposing to cardiovascular morbidity and mortality [4]. RDW is effectively a free test; it is reported alongside a complete blood count at no extra costs, with good prognostic value even compared with relatively expensive inflammatory markers.…”

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confidence: 99%

Red Cell Distribution Width: A Predictor of All-Cause Mortality in Patients with Coronary Artery Disease

Balta

Aparcı²,

Öztürk³

et al. 2014

Cardiology

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Active Matrix Metalloproteinase-9 Is Associated with Clinical In-Stent Restenosis

Cited by 2 publications

References 13 publications

The predictive role of cardiac fibrosis markers in progression of coronary heart disease associated with cardiac arrhythmias and arterial hypertension

The predictive role of cardiac fibrosis markers in progression of coronary heart disease associated with cardiac arrhythmias and arterial hypertension

Red Cell Distribution Width: A Predictor of All-Cause Mortality in Patients with Coronary Artery Disease

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