Active Metabolites from Dunalia spinosa Resinous Exudates

Abstract

Dunalia spinosa, a plant used in folk medicine for toothaches, breathing problems and cleansing wounds, was found active as antimicrobial and antioxidant. A new (E)-aurone rutinoside (dunaurone) has been isolated from the aerial parts of the plant, and its structure was determined by spectroscopic means. Lupeol, ß-sitosterol, scopoletin, quercetin and withaferin A were also found. All the extracts exhibited strong antimicrobial activity while dunaurone showed only weak antimicrobial inhibition against Klebsiella pneumoniae; in addition it presented a significant free radical scavenging activity.

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

“…It is found in edible vegetables and fruits such as white cabbage, pepper, cucumber, tomato, carrot, pea, bitter root, soy bean, ivy gourd, black tea, figs, strawberries, red grapes, mulberries, date palm and guava. Lupeol is also found in abundance in medicinal plants such as Shea butter plant, licorice, Tamarindus indica, Celastrus paniculatus, Zanthoxylum riedelianum, Allanblackia monticola, Himatanthus sucuuba, Leptadenia hastata, Crataeva nurvala, Bombax ceiba, Sebastiania adenophora, Aegle marmelos and Emblica officinalis (Erazo et al 2008;Saleem 2009). …”

Identification of Acarcidal Compounds in Inula japonica Extracts against Tetranychus cinnabarinus

“…Furthermore, Lupeol and Sitosterol were isolated from the petroleum ether extract of Sapium baccatum leaves, and both of them showed high activity in brine shrimp lethality bioassay (Yunus et al 2009). Strong antimicrobial activity was detected both in Lupeol and β-Sitosterol isolated from Dunalia spinosa (Erazo et al 2008). Lupeol from Curtisia dentata was also reported as an antibacterial and antifungal triterpenoid (Shai et al 2008).…”

Potential Anticancer Properties and Mechanisms of Action of Withanolides

“…1B), was first isolated from W. somnifera and its structure was elucidated [4]. In addition to W. somnifera, WFA has been isolated from Withania artistata [5], Ajuga bracteosa [6], Vassobia breviflora [7], and Dunalia spinosa [8]. WFA has shown to have potent cytotoxic effects on various cancer cell types.…”