Active Pharmaceutical Ingredient Cost of Goods: Discovery to Early Development

Anderson, Neal G.; Nelson, Todd D.

doi:10.1002/9783527801756.ch4

Cited by 2 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DATCOM (data compendium) method [46] is used when the wing has a symmetrical airfoil. The method developed by Anderson et al [47] is used for non-symmetric or supercritical airfoils. The comparatively simpler Anderson method can easily be adapted with additional factors for application to unconventional airfoils.…”

Section: Flight Control Systemmentioning

confidence: 99%

“…The galley, entertainment, and furnishing contribute significantly towards the aircraft's overall weight. The method used by Anderson et al [47] has applications specifically to larger aircraft and overpredicts the weight of these systems for smaller commuter aircraft. This paper considers the weight build-up of the subsystems based on the number of passengers, the number of crew, and cabin volume.…”

Section: Electrical Power Consumer Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Systems Integration Framework for Hybrid-Electric Commuter and Regional Aircraft

2023

View full text Add to dashboard Cite

System integration is one of the key challenges to bringing future hybrid-electric and all-electric aircraft into the market. In addition, retrofitting and redesigning existing aircraft are potential paths toward achieving hybrid and all-electric flight, which are even more challenging goals from a system integration perspective. Therefore, integration tools that bridge the gap between the aircraft and the subsystem level need to be developed for use in the conceptual design stage to address current system integration challenges, such as the use of space, the share between propulsive and secondary power, required level of electrification, safety, and thermal management. This paper presents a multidisciplinary design analysis (MDA) framework that integrates aircraft and subsystem sizing tools. In addition, this paper includes improved physics-based subsystem sizing methods that are also applicable to smaller, commuter, or regional aircraft. The capabilities of the developed framework and tools are presented for a case study covering the redesign of the DO-228 with a hybrid-electric propulsion system in combination with the electrification of its systems architecture and different subsystem technologies.

show abstract

Section: Flight Control Systemmentioning

confidence: 99%

Section: Electrical Power Consumer Systemsmentioning

confidence: 99%

Systems Integration Framework for Hybrid-Electric Commuter and Regional Aircraft

2023

View full text Add to dashboard Cite

show abstract

“…There may be only a few kilograms of expensive material in existence. 3 The needs of patients make it a difficult, and unlikely, decision to spare the ca. 800 g required by GSK's internal processes for fire and explosion testing.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, material is in short supply. There may be only a few kilograms of expensive material in existence . The needs of patients make it a difficult, and unlikely, decision to spare the ca.…”

Section: Introductionmentioning

confidence: 99%

Predicting the Fire and Explosion Properties of Early-Phase Active Pharmaceutical Ingredients

Janes

Flanagan

Payne

et al. 2021

Org. Process Res. Dev.

View full text Add to dashboard Cite

Early-phase drug product (DP) manufacture from an active pharmaceutical ingredient (API) is often performed in the absence of fire and explosion data, as material for testing either does not exist or cannot be spared. This leads to onerous processing restrictions, as properties are assumed to be "worst case" or processes are run with an inadequate basis of safety, leading to accidents. Full testing for fire and explosion properties uses about 800 g of material. This paper discusses predictive methodologies used by GSK R&D based on chemistry knowledge and experiments using <1 g of material to identify "materials of concern" (e.g., low minimum ignition energy or adverse dust explosion properties) that require additional safety measures or accelerated testing. The methodology has been employed on over 20 compounds in GSK R&D.

show abstract

Active Pharmaceutical Ingredient Cost of Goods: Discovery to Early Development

Cited by 2 publications

References 24 publications

Systems Integration Framework for Hybrid-Electric Commuter and Regional Aircraft

Systems Integration Framework for Hybrid-Electric Commuter and Regional Aircraft

Predicting the Fire and Explosion Properties of Early-Phase Active Pharmaceutical Ingredients

Contact Info

Product

Resources

About