Active Pharmacological Principle Released by Different Enzymatic Preparations from Bothrops Jararaca Plasma

Kinins in Nature

“…Kallikreins could be species specific, and finally, the kinin-like substance generated could be active in the animal from which it was generated or in certain bioassays but inactive in the screening test employed. LAVRAS et al (1970) could not generate a kinin from plasma of the snake Bothrops jararaea by contact activation or by incubation with either trypsin or the snake venom, procedures which actively generate kin ins in mammalian plasma. However, when they incubated the snake plasma with hog pancreatic kallikrein, Nagarse, or bacterial fibrinolysin, a peptide was generated which, unlike bradykinin, was more active on guinea pig ileum than on rat uterus, contracted rat duodenum, was hypertensive in rat, and did not increase vascular permeability.…”